AIRR Sequencing Researcher
1 day ago
This is an exciting opportunity to contribute to cutting-edge research in the field of adaptive immunity. As an AIRR Sequencing Scientist, you will play a crucial role in developing high-throughput workflows and generating datasets from adaptive immune cells using next-generation sequencing technologies.
Responsibilities:- Design and prepare DNA and RNA libraries from immune cells.
- Perform in-house QC checks and maintain high standards for sequencing quality.
- Help establish and optimize sequencing workflow SOPs for NGS assays.
- Aid in maintaining sequencer uptime and manage reagent inventory.
- Contribute to the development of novel NGS and multiomics assays and research.
- Assist in procurement and maintenance of supplies, chemicals, and biological inventories.
- Communicate study findings efficiently and present data at various internal and external meetings.
- Demonstrate a commitment to diversity, inclusion, and cultural awareness.
- BS, MS, or PhD in biomedical engineering, genetics, immunology, or related field.
- High proficiency with nucleic acid preparation from eukaryotic sources.
- Experience with library design and preparation for next-generation sequencing.
- Familiarity with state-of-art methodology for bulk RNA-seq, single cell RNA-seq, and AIRR/BCR/TCR profiling.
- Experience processing diverse single-cell raw data using Cell Ranger and alternative/open-source pipelines.
- Comfort running multiple projects simultaneously with different priorities and timelines.
- Strong organizational, time management, and communication skills.
- Prior experience in adaptive immunity research.
- Familiarity with diverse next-generation sequencing technologies.
- Experience with single-cell multiomics techniques, long-reads, and/or proteomic antibody sequencing.
- Familiarity with diverse microfluidics, microwell, and microfluidics-free platforms.
- Experience with liquid handling automation for sequencing library preparation.
- Proficiency in custom protocol development.
- Experience with novel assay development.
- Competence in R and/or Python with familiarity with scVerse tools, scVi tools, Scanpy, or Seurat, as well as antigen-specific analysis using scRepertoire, Immcantation, or related tools.
- Competitive compensation $90,000 - $120,000 a year.
- Excellent medical, dental, and vision insurance.
- Generous time off + paid holidays.
- A supportive environment to learn and develop new skills.
- An opportunity to participate in high-impact, fast-paced, cutting-edge, collaborative team science.
- Exciting location in the Soho area of Manhattan.
We aim to help fill a structural gap in today's R&D system by enabling fundamental research that requires unusual levels of scale and coordination yet is not rapidly monetizable by industry. We're bringing together top talent from academia, industry, and startups to build a new model for innovative R&D.
We are an Equal Employment Opportunity employer that proudly pursues and hires a diverse workforce. We do not make hiring or employment decisions on the basis of race, color, religion or religious belief, ethnic or national origin, nationality, sex, gender, gender-identity, sexual orientation, disability, age, military or veteran status, or any other characteristic protected by applicable local, state, or federal law or company policy.
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