Medicinal Chemistry Research Specialist

2 weeks ago


South San Francisco, California, United States Septerna Inc. Full time

POSITION OVERVIEW


We are looking for a skilled medicinal chemist to enhance our chemistry initiatives for various drug discovery projects, collaborating within a multidisciplinary team.

Your responsibilities will include the design of novel compounds, conducting synthesis in our in-house laboratories, partnering with Contract Research Organizations (CROs), and providing comprehensive support to our chemistry department.

This role presents a remarkable opportunity to gain insights from seasoned medicinal chemists and drug discovery experts, utilizing structure-based drug design, contemporary hit-identification methodologies (such as virtual screening and DNA-encoded libraries), and advanced pharmacological techniques targeting GPCRs to meet significant medical challenges.


ESSENTIAL QUALIFICATIONS


In-depth knowledge and practical experience in synthetic organic chemistry, encompassing modern synthetic techniques, multi-step synthetic route development, compound purification, and characterization.

Proven ability to independently conceptualize, implement, and troubleshoot effective synthetic pathways for drug-like compounds.


Strong analytical capabilities and proficiency in organizing and interpreting structure-activity relationship (SAR) datasets to inform design strategies.

Willingness to learn and utilize computational modeling and SAR analysis tools to create compounds that influence program direction.

Exceptional communication skills with a track record of delivering impactful presentations.


A collaborative mindset, demonstrating a team-oriented approach while being mindful of team dynamics.


Potential for leadership in managing external CRO chemistry resources.



EDUCATIONAL BACKGROUND
Ph.D. in synthetic organic chemistry or medicinal chemistry, with or without postdoctoral experience (experience in the biotech/pharmaceutical sector and familiarity with structure-based drug design is advantageous); or a BS/MS with over 6 years of relevant experience in the biotech/pharmaceutical industry.

The expected salary range for candidates is between $120,000 and $145,000.

Individual compensation may vary based on various factors, including job-related skills, experience, work location, and relevant education or training.

Septerna's compensation package also includes benefits, stock options, and an annual target bonus for full-time roles.

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