Research Scientist, Translational Medicine

5 days ago


Cambridge, Massachusetts, United States Bicycle Therapeutics Limited Full time
Job Title: Research Scientist, Translational Sciences

Bicycle Therapeutics Limited is a clinical-stage biopharmaceutical company dedicated to developing innovative medicines for underserved diseases. We are seeking a highly skilled Research Scientist to join our Translational Sciences team.

Job Summary

The successful candidate will be responsible for overseeing data generation, analysis, and interpretation of clinical protocol-defined biomarker assays, managing clinical trial biomarker samples, and overseeing external assay development projects at Contract Research Organizations (CROs). This is a key role in our multifaceted team that works seamlessly across research and clinical functions to support clinical biomarker strategies.

Key Responsibilities
  • Design, conduct, and coordinate translational research activities at CROs, including assay development, execution, and analysis of clinical biomarker data.
  • Identify, evaluate, and prioritize candidate predictive & pharmacodynamic biomarkers to support clinical development strategies.
  • Support analysis and development of clinical biomarker datasets, including Next-Generation Sequencing (NGS), Immunohistochemistry (IHC), and In Situ Hybridization (ISH).
Requirements
  • Essential requirements:
  • Experience with design, delivery, analysis, and interpretation of clinical biomarker assay techniques (e.g., comprehensive genomic profiling/NGS, ISH, and/or IHC).
  • Clinical biomarker assay development experience in solid tumor/liquid biopsies.
  • Demonstrated experience managing external projects at CROs.
  • Translational science, translational medicine, or clinical research experience.
  • Ability to collaborate, communicate, and present findings to scientists and non-scientists.
  • Flexible, organized, and motivated scientist who enjoys working in a fast-paced, small company environment.
What We Offer
  • Flexible working environment.
  • Competitive reward, including annual company bonus.
  • Medical, dental, and vision insurance for eligible employees and their families, with 100% of the premiums covered by the Company.
  • Health and Dependent Care Flexible Spending Accounts.
  • 401(k) plan with a 4% Company match and immediate vesting.
  • Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days.
  • Employee assistance program.
  • Employee recognition schemes.
  • 10 Company holidays.
  • Competitive Family Leave Policy.
  • Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.

Bicycle Therapeutics Limited is an equal opportunities employer and welcomes applications from all qualified candidates. We are committed to building a diverse workforce that is representative of the communities we serve.



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