Biomarker Researcher

2 days ago

Cambridge, Massachusetts, United States QurAlis Full time

About QurAlis

We are a clinical-stage biotechnology company advancing a pipeline with therapeutic candidates that target specific components of ALS and FTD pathology and defined patient populations based on both disease-causing genetic mutation(s) and clinical biomarkers.

Job Summary

We are seeking a highly motivated Biomarker Scientist to support and execute our CNS Biomarker discovery program. The successful candidate will develop translational strategies for novel therapeutics to assess pharmacodynamics, patient selection criteria, and mechanism of action.

Key Responsibilities

  • Plan and execute experiments, contributing high-level scientific neurodegeneration pathways expertise
  • Develop assays for customized, highly sensitive RNA and protein quantification
  • Design and implement discovery plans, overseeing their execution
  • Analyze data, interpret results, identify problems, and develop creative troubleshooting plans
  • Identify contract research vendors and manage contract research studies
  • Proactively review the scientific field to identify and share new scientific findings, ideas, and methods with other scientists at QurAlis
  • Collaborate with clinical experts to translate biomarker plans
  • Communicate effectively across the organization with translational medicine, clinical development, and discovery teams
  • Present research findings internally and externally at scientific meetings/conferences

Requirements

  • PhD in cell biology, molecular biology, biochemistry, neuroscience, or a related field
  • 3-5 years of relevant experience in academic and/or industry settings, including experience in neurodegenerative disease mechanisms, disease modeling, drug discovery, or assay development
  • Proven track record of scientific excellence, as evidenced by high-impact, peer-reviewed publications
  • Proactive, willingness to contribute to bench work in the lab
  • Ability to work independently and collaboratively in cross-functional teams
  • Strong organizational skills, work ethic, and high-level motivation
  • Capacity to be highly productive in a dynamic and fast-paced work environment
  • Comfortable working in or leading matrix teams
  • Excellent oral, written, and interpersonal communication skills
  • Authorized to work legally in the United States

Desired Qualifications

  • Hands-on experience developing and troubleshooting customized RNA or protein high-throughput assays
  • Expertise in extracellular vesicle isolation methods from biofluids or cell culture media
  • Previous experience managing multiple outsourced projects while maintaining timelines and milestones
  • Experience progressing an assay from development to analytical validation

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