Senior Scientist, Translational Medicine Expert
2 weeks ago
We are seeking a highly skilled Senior/Principal Scientist to lead lab-based translational research and discovery efforts in the clinical proteomics and mass spectrometry laboratory at Genentech.
This is a hands-on, lab-based position that requires close collaboration with colleagues and departments across multiple functions in Genentech Research & Early Development (gRED). As an integral member of this dynamic team, you will:
- Design and execute mass spectrometry/clinical proteomics experiments to explore novel biomarker hypotheses and collaborate with other Translational Medicine Scientists and Biomarker Teams to interpret biological results to enable a fundamental understanding of disease biology.
- Generate large clinical proteomics datasets to answer key questions important for drug development using state-of-the-art instrumentation and analysis tools.
- Drive innovation within the group through developing new approaches and bringing in novel instrumentation and streamline existing workflows using automation.
- Collaborate with other mass spectrometry/clinical proteomics team members to deliver impactful results and train others on new methodologies.
- Leverage internal and external partners (CROs) to increase internal bandwidth and impact across the portfolio.
Requirements
- You hold a PhD in Analytical Chemistry, Biochemistry, or Biotechnology and have successfully completed postdoctoral research in a related field, 3+ years (Senior Scientist) 6+ years (Principal Scientist) of hands-on experience with liquid chromatography and tandem mass spectrometry (LC-MS/MS) approaches.
- Experienced in clinical proteomics and clinical sample processing with excellent troubleshooting capabilities with a deep understanding of the fundamentals in assay development, system suitability, and novel technology evaluation.
- Experienced with discovery proteomics approaches (DIA-MS, TMT, SWATH, etc.) and corresponding data analysis tools, and knowledgeable in sample preparation techniques for analyzing biomarkers and other mediators from biological fluids (e.g., plasma, CSF, urine, stool, etc.).
- Experienced in analyzing and visualizing complex datasets using tools like MSstats, Spotfire, R, and Skyline, with proficiency in standard instrument software such as Analyst and Xcalibur. Possess strong communication, presentation, and interpersonal skills, with the ability to work both independently and collaboratively.
Relocation benefits are available for this job posting.
The expected salary range for this position based on the primary location of South San Francisco, California is $120,700-$224,100 (Senior Scientist) and $141,500-$262,900 (Principal Scientist). Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.
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