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Senior Research Scientist, Translational Pharmacology
2 months ago
AnaptysBio Inc is seeking a highly skilled Senior Research Scientist to join our Translational Pharmacology team. As a key member of our research team, you will be responsible for designing, performing, and interpreting in vitro cellular functional assays to achieve program goals.
Key Responsibilities- Develop and execute cell-based functional assays with cell lines, primary cells, whole blood, PBMCs, and sub-populations of immune cells from both normal and disease donors to understand the biology of targets and evaluate the pharmacology of lead antibody candidates.
- Evaluate activity of antibodies from AnaptysBio's discovery platforms to support antibody drug screening, target validation, mechanism-of-action studies, biomarker identification, and/or companion diagnostics development.
- Collaborate effectively with team members in other departments to achieve program goals and present experimental results and make recommendations for action/further research at project and department meetings.
- Prepare research reports for transfer to external CRO/collaborators, patent applications, and posters/manuscripts.
- Bachelor's degree in a relevant scientific discipline (biology, immunology, translational pharmacology, or related field) with 10 years related laboratory experience or equivalent.
- Deep knowledge and working experience in principles and techniques of cellular immunology, cell biology, and translational pharmacology.
- Experience in industry drug discovery workflow, from linking antibody screening to in vitro/in vivo translational assays that support program advancement and IND filing.
- Ex vivo human or animal explant systems to evaluate tissue pharmacology.
- Quantitative pharmacology of target and therapeutic antibody trafficking using live-cell imaging, high-content imaging, and immune synapse formation assays.
- Development of PK/ADA assays for therapeutic antibodies.
- Molecular immunology to support translational medicine approaches.
The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
While performing the duties of this job, the employee is regularly required to sit and talk or hear. The employee frequently is required to use hands to finger, handle, or feel. The employee is occasionally required to stand, walk, and reach with hands and arms. The employee must occasionally lift and/or move up to 10 pounds.
Work EnvironmentThe work environment characteristics are representative of those an employee encounters while performing the essential functions of this job, typically in an open office environment. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
The noise level in the work environment is usually moderate.
May be required to travel by plane or car.
This position requires working with biological and/or chemical hazards.
