Translational Research Scientist

3 days ago


South San Francisco, California, United States Pyramid Consulting, Inc Full time
Job Title: Translational Research Scientist - I

We are seeking a highly skilled Translational Research Scientist - I to join our team at Pyramid Consulting, Inc. in South San Francisco, CA. This is a 12+ months contract opportunity with long-term potential.

Job Summary:

The successful candidate will work in a multidisciplinary, highly collaborative discovery team to invent Client medicines by applying optimized conjugation protocols, analytical techniques, and data analysis to synthesize drug candidates and intermediates.

Key Responsibilities:
  • Perform bioconjugations of linker-payload combinations to antibodies with emphasis on in-house established methods.
  • Selection and application of appropriate purification techniques for biologics (i.e., SEC, hydrophobic interaction chromatography, ion exchange chromatography).
  • Acquisition and interpretation of analytical data such as LC/MS.
  • Collaborate with cross-functional teams to design and optimize conjugation protocols.
Requirements and Technology Experience:
  • Minimum qualifications include a B.S./M.S/ PHD in chemistry, biochemistry, or related field, with industrial or academic experience.
  • Hands on experience with conjugation, purification and characterization of antibody drug conjugates, and experience using analytical techniques/instrumentation, including chromatographic techniques such as HIC (Hydrophobic Interaction Chromatography) and RP (Reverse Phase), SEC, SDS-PAGE, UV‐Vis.
  • Nice to have skills: Biologics analytic experience, purification techniques.
  • Must have: Bio-conjugation experience, protein biochemistry and Chemistry background.

Pyramid Consulting, Inc. provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.



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