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Senior Scientist, Translational Pharmacology Specialist
2 months ago
AnaptysBio Inc is seeking a highly skilled Senior Scientist, Translational Pharmacology Specialist to join our team. As a key member of our translational pharmacology group, you will be responsible for designing, performing, interpreting, and recording in vitro cellular functional assays with lead candidate antibodies to achieve program goals.
Key Responsibilities- Develop and execute cell-based functional assays with cell lines, primary cells, whole blood, PBMCs, and sub-populations of immune cells from both normal and disease donors to understand the biology of targets, evaluate the pharmacology of lead antibody candidates, support translational studies, and analyze in vivo pharmacology (PK/PD) relationships.
- Evaluate activity of antibodies from AnaptysBio's discovery platforms to support antibody drug screening, target validation, mechanism-of-action studies, biomarker identification, and/or companion diagnostics development.
- Isolate and purify primary cells from multiple sources (blood, spleen, skin) and species (human, NHP, mouse).
- Perform mammalian tissue culture, including both established cell lines and primary immune cells.
- Develop and optimize in vitro functional assays for T, B cells, myeloid cells, including both basic and more complex coculture systems, such as cell proliferation, cell signaling, and cytokine production.
- Perform high-dimensional flow cytometry (both surface and intracellular markers) and cytokine analysis using ELISA, MSD, and/or Luminex platforms.
- Analyze complex scientific datasets using GraphPad PRISM to interpret translational pharmacology.
- Collaborate effectively with team members in other departments (Molecular Biology, Protein Sciences, Mechanism of Action, In vivo) to achieve program goals.
- Present experimental results and make recommendations for action/further research at project and department meetings.
- Prepare research reports for transfer to external CRO/collaborators, patent applications, and posters/manuscripts.
- Formulate experimental plans to achieve scientific goals in new and creative ways.
- Bachelor's degree in a relevant scientific discipline (biology, immunology, translational pharmacology, or related field) with 10 years related laboratory experience or equivalent.
- Deep knowledge and working experience in principles and techniques of cellular immunology, cell biology, and translational pharmacology (cell culture, in vitro cell-based functional assays, flow cytometry, analyte platforms, familiarity with animal models of autoimmune disease and PK/PD principles).
- Experience in industry drug discovery workflow, from linking antibody screening to in vitro/in vivo translational assays that support program advancement and IND filing.
- Antibody discovery experience in screening assays.
- Scientific independence, ability to work with limited supervision, ability to collaborate effectively within team setting and cross-functionally with other departments.
- Ability to quickly implement standard approaches and ensure experiments are well-designed and performed to a high standard.
- Ability to develop, apply, and troubleshoot new methods to address specific scientific questions.
- Proficiency in data analysis and presentation applications (Flowjo, Diva, Novoexpress, etc.; ELN/Benchling, Word, Excel, Powerpoint).
- Ex vivo human or animal explant systems to evaluate tissue pharmacology (for example involving TEER, cell migration, organoids, fibrosis).
- Quantitative pharmacology of target and therapeutic antibody trafficking using live-cell imaging, high-content imaging, and immune synapse formation assays.
- Development of PK/ADA assays for therapeutic antibodies.
- Molecular immunology to support translational medicine approaches (scRNAseq, spatial transcriptomics, multiplex IHC).
- Development of new methods for antibody discovery leveraging novel molecular and/or cell biology.
- Management/mentorship of more junior scientists.
