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Senior/Principal Scientist, Translational Medicine and Biomarker Development
2 months ago
We are seeking a highly motivated and experienced Senior/Principal Scientist to lead lab-based translational research and discovery efforts in the clinical proteomics and mass spectrometry laboratory at Genentech.
Key Responsibilities- Design and Execute Mass Spectrometry/Clinical Proteomics Experiments: Develop and execute mass spectrometry/clinical proteomics experiments to explore novel biomarker hypotheses and collaborate with other Translational Medicine Scientists and Biomarker Teams to interpret biological results.
- Generate Large Clinical Proteomics Datasets: Generate large clinical proteomics datasets to answer key questions important for drug development using state-of-the-art instrumentation and analysis tools.
- Drive Innovation and Automation: Drive innovation within the group through developing new approaches and bringing in novel instrumentation to streamline existing workflows using automation.
- Collaborate with Team Members: Collaborate with other mass spectrometry/clinical proteomics team members to deliver impactful results and train others on new methodologies.
- Leverage Partnerships: Leverage internal and external partners (CROs) to increase internal bandwidth and impact across the portfolio.
- PhD in Analytical Chemistry, Biochemistry, or Biotechnology: Hold a PhD in Analytical Chemistry, Biochemistry, or Biotechnology and have successfully completed postdoctoral research in a related field.
- Hands-on Experience with LC-MS/MS: Have 3+ years (Senior Scientist) 6+ years (Principal Scientist) of hands-on experience with liquid chromatography and tandem mass spectrometry (LC-MS/MS) approaches.
- Clinical Proteomics Expertise: Experienced in clinical proteomics and clinical sample processing with excellent troubleshooting capabilities and a deep understanding of the fundamentals in assay development, system suitability, and novel technology evaluation.
- Discovery Proteomics Approaches: Experienced with discovery proteomics approaches (DIA-MS, TMT, SWATH, etc.) and corresponding data analysis tools, and knowledgeable in sample preparation techniques for analyzing biomarkers and other mediators from biological fluids.
- Strong Communication and Interpersonal Skills: Possess strong communication, presentation, and interpersonal skills, with the ability to work both independently and collaboratively.
