Senior Principal Scientist, Translational Medicine and Cardiovascular Diseases
1 week ago
We are seeking a highly skilled and experienced Senior Principal Scientist to join our Translational Medicine and Cardiovascular Diseases team at Genentech. As a key member of our team, you will play a critical role in advancing our understanding of disease biology and developing impactful contributions to clinical drug development.
Key Responsibilities- Partner with Research to lead preclinical biomarker discovery and development efforts, supporting research programs in cardiovascular and metabolic diseases.
- Develop and lead early and late-stage clinical development decision-enabling biomarker strategies, integrating biomarker activities in clinical trials, generating biomarker data, and leading the analysis, interpretation, and presentation of results.
- Collaborate with global development teams to address key questions during late-stage clinical development, including product differentiation, indication expansion, and patient response.
- Participate in or initiate external collaborations related to understanding disease pathogenesis and patient heterogeneity.
- Serve as the biomarker lead on cross-functional project teams and internal review committees.
- Collaborate closely with internal partners, including Research, Bioanalytical Sciences, Clinical Sciences, Preclinical and Clinical Pharmacology, Biostatistics, Regulatory, and Bioinformatics, as well as with external partners.
- Write biomarker sections of clinical and non-clinical protocols, reports, and regulatory filings, publish results in high-quality journals, and present at external conferences.
- PhD, MD, or MD/PhD in Endocrinology, Cell Biology, Physiology, or related fields with 6+ years post-doctoral, fellowship, or industry experience and prior experience with translational research and/or clinical trials for cardiovascular and metabolic diseases.
- Experience in, and deep technical understanding of, preclinical and clinical sample collection/processing and cellular/molecular lab techniques such as cell culture, primary cell isolation from tissues, immunostaining, molecular biology, ELISA, western blot, flow cytometry, genomic sequencing, qRT-PCR, and/or transcriptomics.
- Demonstrate a high level of independence with ability to develop hypotheses, direct lab scientists, develop analysis plans, interpret, and present results.
- Preferred candidates will have prior biostatistics or bioinformatics experience (omics, pathway, network analysis, etc.) with programming skills in Python or R.
- Strong written and verbal communication skills, as evidenced by publications, external presentations, and drug development reports, are required, along with extensive experience in leading R&D teams and fostering internal collaborations and partnerships with academic universities.
- Willingness to collaborate across time zones, including our Swiss site, is a must.
Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. We prohibit unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status, and veteran status.
Relocation benefits are available for this position. The expected salary range for this position based on the primary location of South San Francisco, California is $176,600-$328,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
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