Research Scientist

7 days ago

Seattle, Washington, United States ECLARO Full time

JOB TITLE: Associate Research Scientist

Location: Seattle, WA (100% Onsite)

Duration: 12 months initial (potential extension/potential right to hire)

Key Competencies:


• Extensive proficiency in HPLC/UPLC methodologies.


• Knowledge of nanoparticle characterization techniques such as DLS, MALS-FFF, NTA, and encapsulation efficiency.


• Experience in mammalian cell-based assays with flow cytometric analysis.


• Familiarity with ELISA techniques.


• Expertise in the downstream purification of biological entities, including AKTA, chromatography, TFF, and viral filtration.

The Associate Scientist will be part of the Gene Delivery and Editing Process Development (GDEPD) team, focusing on analytical advancements for the production and characterization of lipid nanoparticles (LNPs) and related process residuals, which are vital for developing innovative cell therapies.

This role involves collaboration within the LNP Platform Development team, driving initiatives aimed at enhancing next-generation LNP platforms, particularly in gene editing. The associate will gain hands-on experience in developing and executing analytical assays for LNP characterization while becoming acquainted with LNP process development techniques. Additionally, the role offers exposure to various gene editing technologies, fostering collaboration across diverse process development teams.

Responsibilities:


• Execute and troubleshoot analytical assays for LNP characterization (HPLC/UPLC, DLS, fluorescence-based methods, etc.).


• Assist in designing and evaluating new analytical development assays for LNPs.


• Establish protocols for analytical assays.


• Manage sample flow, data collection, and analysis.


• Optimize workflows for assessing LNP characteristics.


• Participate in lab maintenance and continuous improvement efforts.


• Maintain a detailed and accurate laboratory notebook and documentation.


• Summarize and present findings in team meetings and contribute to strategic discussions.


• Author technical reports, protocols, and study documentation.

Basic Qualifications:


• STEM degree with a minimum of 2 years of relevant industry experience; title and compensation will be aligned with education, experience, and skillset.


• Proven experience with HPLC/UPLC.


• Familiarity with nanoparticle characterization techniques.


• Self-motivated with the ability to work collaboratively.


• Strong communication skills, both oral and written.


• Ability to utilize literature and resources to address challenges.


• A passion for advancing innovative technologies.


• A growth mindset and adaptability in a dynamic, collaborative environment.

Preferred Qualifications:


• Degree in biological or chemical engineering, biochemistry, or a related field.


• Experience with mammalian cell-based assays.


• Proficiency in ELISA techniques.


• Knowledge of downstream purification processes for biological molecules.


• Experience with mammalian cell culture techniques.


• Familiarity with the production and purification of LNPs.

Benefits:

  • 401k Retirement Savings Plan administered by Merrill Lynch
  • Commuter Check Pretax Commuter Benefits
  • Eligibility for Medical, Dental & Vision Insurance through Eclaro

Equal Opportunity Employer: Eclaro values diversity and does not discriminate based on Race, Color, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Age, Genetic Information, Disability, Protected Veteran Status, or any other legally protected group status.

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