Senior Principal Research Scientist, Cancer Cell Programs

5 days ago

San Diego, California, United States Pfizer Full time
About the Role

We are seeking a highly experienced and accomplished Senior Principal Scientist to join our Post-CAN Research group at Pfizer's Oncology Research Unit in La Jolla, California. As a key member of our team, you will lead preclinical research and translational oncology efforts to advance our clinical and pre-clinical drug programs in the field of cancer cell biology.

Key Responsibilities
  • Develop innovative strategies for understanding the role of cell signaling and/or cell cycle targets in cancer progression, drug resistance, and immune modulation.
  • Lead preclinical research for oncology assets to advance mechanism of action studies, develop patient responder hypotheses, elucidate mechanisms of resistance, and identify rational drug combinations.
  • Provide scientific leadership and serve as biology lead for post-candidate programs in cross-functional Global Product Teams to support asset clinical development.
  • Interface with groups of discovery biology, discovery technologies, computational biology, in vivo pharmacology, drug pharmacokinetics, and drug safety to design experiments and interpret datasets to advance pipeline projects.
  • Work collaboratively with translational oncology to integrate complex preclinical and clinical datasets and support reverse translation efforts.
  • Actively contribute to the regulatory strategy for projects and may author key regulatory submission documents (IND, IB, etc.) needed to support candidate development.
  • Proactively seek out new information in the literature and incorporate learnings to progress preclinical research and MOA understanding of the target.
  • Present research findings and share learnings at research project team meetings, post-CAN biology meetings, and other broader research forums.
Requirements
  • PhD or MD/PhD in Molecular or Cellular Biology, Genetics, Pharmacology (or a comparable biological science) with 7+ years of relevant postdoctoral experience in an pharmaceutical/biotech or academic environment.
  • Expertise in cell signaling and/or cell cycle biology as evidenced by publication in peer-reviewed journals.
  • Preference for candidates with a strong track record in oncology translational research and/or drug discovery in the field of cell cycle/cell signaling pathways.
  • Strong ability to multi-task, lead biology research activities across multiple programs in collaboration with different partner lines.
  • Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
Preferred Qualifications
  • Experience in leading preclinical translational oncology research and working with cross-functional clinical development teams.
  • Knowledge of other areas of cancer biology and relevant clinical landscape including oncogenic signaling, DNA repair, cancer epigenetics, and ADC biology.
  • Experience supporting regulatory submissions and authoring of IND study reports.
  • Managerial experience, preferably in industry setting.
About Pfizer

Pfizer is a global biopharmaceutical company that applies science and innovation to make a meaningful difference in the lives of people. We are committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability, or veteran status.

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