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Research Scientist/Senior Research Scientist, Biologics/Immuno-Oncology Expert
2 months ago
We are seeking a highly skilled Research Scientist/Senior Research Scientist to join our team at Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research. This is an exciting opportunity to work in the field of immuno-oncology and biologics, contributing to the development of innovative cell and protein therapies for the treatment of cancer.
Key Responsibilities- Design and execute project plans involving immune cell profiling, cell processing from xenograft models, cytotoxicity, proliferation, activation, cell viability, and survival assays with a strong focus on flow cytometry.
- Gene editing of primary human immune cells using state-of-the-art technologies like CRISPR, TALEN, and other endonucleases while using multiple delivery approaches including protein and mRNA electroporation and multiple viral vector platforms.
- Generation of reagents for projects including preparation of lentivirus for the transduction of both established cell lines and primary immune cells.
- Molecular biology experiments including DNA and protein preparation from cells, immunoprecipitation, western blots, etc will be within the scope of work.
- Preparation of reports and presentation of results at regular team meetings.
- A strong background in cell culture and multi-color flow cytometry is essential.
- Hands-on experience with in vitro assays (co-culture assays) commonly used in immuno-oncology is essential.
- Experience and knowledge of the immune system is essential (Experience in T/B/NK/macrophage cell biology, tumor immunology).
- Experience with protein engineering and antibody design is important.
- Experience with molecular biology techniques is important.
- Hands-on experience with cellular immunotherapies is preferred.
- Experience with gene editing, cell transfection and transduction systems is preferred but not required.
- Experience preparing reagents for in vivo assays and in vivo experience preferred but not required.
- Experience using Prism, FlowJo, Office, and JMP software is important.
- Bachelor's degree in biology, chemical biology, biochemistry, or related field required. PhD is highly preferred.
- Minimum 2 years' experience in the industry required.
- Impeccable attention to detail, and excellent ability to perform hands-on experiments, research, design, and organize project designs and maintain detailed documentation.
- Highly motivated, creative, and devoted to project goals.
- Able to collaborate proficiently and communicate effectively with colleagues and management teams.
- Able to contribute in a meaningful way to scientific discourse.
- Employer Contributed Retirement Plan – Depending on eligibility, employees receive an employer contributed retirement plan (no employee contribution required) and the option to contribute to a 403(b) (which is similar to a 401(k) using your own pre or post-tax dollars)
- Full Suite of Health and Welfare plans including three medical plan options (including an HSA available option), dental, vision, life insurance, disability, EAP and more
- Access to Flexible Spending Accounts (Medical/Dependent Care)
- Competitive vacation and sick leave policies
- Free, on-site parking