Research Scientist/Senior Research Scientist, Biologics/Immuno-Oncology Expert

1 week ago

San Diego, California, United States Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research Full time
Job Summary

We are seeking a highly skilled Research Scientist/Senior Research Scientist to join our team at Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research. This is an exciting opportunity to work on cutting-edge projects in the field of immuno-oncology, leveraging your expertise in cell biology, molecular biology, and protein engineering.

Key Responsibilities
  • Design and execute project plans involving immune cell profiling, cell processing from xenograft models, cytotoxicity, proliferation, activation, cell viability, and survival assays with a strong focus on flow cytometry.
  • Gene editing of primary human immune cells using state-of-the-art technologies like CRISPR, TALEN, and other endonucleases while using multiple delivery approaches including protein and mRNA electroporation and multiple viral vector platforms.
  • Generation of reagents for projects including preparation of lentivirus for the transduction of both established cell lines and primary immune cells.
  • Molecular biology experiments including DNA and protein preparation from cells, immunoprecipitation, western blots, etc will be within the scope of work.
  • Preparation of reports and presentation of results at regular team meetings.
Requirements
  • A strong background in cell culture and multi-color flow cytometry is essential.
  • Hands-on experience with in vitro assays (co-culture assays) commonly used in immuno-oncology is essential.
  • Experience and knowledge of the immune system is essential (Experience in T/B/NK/macrophage cell biology, tumor immunology).
  • Experience with protein engineering and antibody design is important.
  • Experience with molecular biology techniques is important.
  • Hands-on experience with cellular immunotherapies is preferred.
  • Experience with gene editing, cell transfection and transduction systems is preferred but not required.
  • Experience preparing reagents for in vivo assays and in vivo experience preferred but not required.
  • Experience using Prism, FlowJo, Office, and JMP software is important.
Qualifications
  • Bachelor's degree in biology, chemical biology, biochemistry, or related field required. PhD is highly preferred.
  • Minimum 2 years' experience in the industry required.
  • Impeccable attention to detail, and excellent ability to perform hands-on experiments, research, design, and organize project designs and maintain detailed documentation.
  • Highly motivated, creative, and devoted to project goals.
  • Able to collaborate proficiently and communicate effectively with colleagues and management teams.
  • Able to contribute in a meaningful way to scientific discourse.
Benefits
  • Employer Contributed Retirement Plan – Depending on eligibility, employees receive an employer contributed retirement plan (no employee contribution required) and the option to contribute to a 403(b) (which is similar to a 401(k) using your own pre or post-tax dollars)
  • Full Suite of Health and Welfare plans including three medical plan options (including an HSA available option), dental, vision, life insurance, disability, EAP and more
  • Access to Flexible Spending Accounts (Medical/Dependent Care)
  • Competitive vacation and sick leave policies
  • Free, on-site parking

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