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Senior Research Scientist, Cell and Gene Therapy
2 months ago
Novartis Biologics Center (BRC) is seeking a highly skilled and experienced Senior Research Scientist to join our Cell and Gene Therapy (CGT) group in San Diego, CA. As a key member of our team, you will have the opportunity to contribute to the development of innovative medicines for patients with devastating diseases.
Key Responsibilities- Lead and contribute to the development of next-generation CGT delivery improvement projects across multiple Novartis sites.
- Undertake and lead efforts to develop more potent, safer, and tolerable LVV and AAV vectors.
- Enable translation from in vitro/in vivo mouse and nonhuman primate POC studies to therapeutic disease programs for preclinical development.
- Initiate, lead, and contribute to interdisciplinary research programs in a highly collaborative and matrixed manner across internal groups and with external partners.
- Prepare reports, manuscripts, and protocols, adhering to good research practices and quality culture across NIBR.
- Present results at appropriate internal and external meetings and conferences.
- Bachelor's degree in cell and gene therapy, bioinformatics, molecular/cell biology, bioengineering, or related scientific field with 12 years industry or equivalent experience.
- Master's degree in cell and gene therapy, bioinformatics, molecular/cell biology, bioengineering, or related scientific field with 10 years industry or equivalent experience.
- PhD with 6 years of industry or equivalent experience.
- Demonstrated expertise in LVV and AAV biology, virology, viral tropism engineering, transcriptional and post-transcriptional mechanisms, and analytical/process development for LVV/AAV production.
- Strong publication, patent, and/or external presentation record.
- Genetic/epigenomic/transcriptomic profiling technologies.
- Genome engineering (e.g. CRISPR).
- Nonviral gene therapy.
- sh/miRNA biology.
- Analytical/process development for LVV/AAV production.
