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Lead Scientist in Oncology Research

2 months ago

San Diego, California, United States RayzeBio Full time

Job Title: Principal Scientist, Biology

Location: San Diego

ID: R7

Company Overview

RayzeBio is an innovative biotechnology firm based in San Diego, CA. Established in late 2020 and now a wholly owned subsidiary of Bristol Myers Squibb (BMS), the organization is dedicated to enhancing the survival rates of cancer patients by leveraging targeted radioisotopes. Operating independently within the BMS framework, RayzeBio maintains its unique biotech culture while benefiting from BMS's premier oncology capabilities. The company is focused on developing cutting-edge therapeutics aimed at solid tumor targets, with its leading asset, RYZ101, currently in Phase 3 trials for gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and in earlier phases for small cell lung cancer (SCLC). Guided by a seasoned entrepreneurial team, RayzeBio aspires to become a global leader in the field of radiopharmaceuticals.

Position Overview

This role presents a unique opportunity to spearhead the biology strategy for pipeline projects, guiding them from target selection to candidate nomination. The ideal candidate will possess extensive experience in biology, complemented by exceptional interpersonal and communication skills. Collaboration with the leadership team will be essential to develop and implement project strategies, forecast resource requirements, and ensure timely delivery of objectives. The position necessitates effective teamwork within interdisciplinary settings and includes mentoring junior staff while providing technical guidance in laboratory settings, particularly in the development, validation, and execution of in vitro assays and oncology models. A willingness to work with radioactive isotopes is also required.

Key Responsibilities

Primary duties and responsibilities include, but are not limited to:

  • Utilizing a comprehensive understanding of cancer biology and oncology drug development to lead target selection and initiate new radiopharmaceutical projects.
  • Collaborating with cross-functional team leaders to provide strategic and operational guidance for project teams focused on specific targets.
  • Working closely with interdisciplinary teams to offer functional biology leadership throughout the lead identification and optimization phases.
  • Assisting in the creation of preclinical GLP/non-GLP data packages to support regulatory submissions and clinical development.
  • Contributing to the formulation of a translational biology plan that aligns with the clinical development strategy.
  • Authoring and reviewing study reports, regulatory documentation, scientific presentations, and publications while managing external research collaborations.
  • Evaluating scientific and research needs for projects and engaging with external partners and key opinion leaders to establish necessary collaborations.
  • Serving as the scientific lead for external partnerships and overseeing scientific projects through outsourcing when required.
  • Driving innovation and novel methodologies in radiopharmaceutical research and development to enhance the company's competitive advantage.
  • Effectively managing internal and external resources and budgets to support corporate objectives.

Qualifications

  • PhD in cancer biology, cell biology, pharmacology, or a related discipline, with a profound understanding of cancer biology and experience in oncology drug development.
  • A minimum of 7 years of experience in pharmaceutical or biotech R&D environments, demonstrating a track record of successful accomplishments and progressive leadership.
  • Experience with targeted cancer therapy modalities such as radiopharmaceuticals, antibody-drug conjugates, and peptide-drug conjugates is highly desirable.

Skills

  • Exceptional written and verbal communication skills, with the ability to thrive in a fast-paced, dynamic, and collaborative environment.
  • Strong interpersonal and organizational skills, with a proven ability to motivate and enhance productivity in small company settings.
  • Expertise in in vitro and cell-based assay development and optimization, along with proficiency in cell culture, molecular biology techniques, ELISA, flow cytometry, western blotting, qPCR, single-cell cloning, and immunohistochemistry.
  • Familiarity with ADME/PK concepts and the drug development process, as well as experience interfacing with regulatory teams.
  • Experience in developing and utilizing in vivo oncology models, with the capability to design and supervise controlled in vivo experiments.
  • Ability to effectively collaborate with clinical, regulatory, CMC, and chemistry/DMPK teams, leading interdisciplinary scientific teams and mentoring junior scientists.
  • Willingness to work with radioisotopes while adhering to strict radiation safety protocols.
  • Proven ability to establish and manage external collaborations, including partnerships with CROs and academic institutions.

Compensation and Benefits

The starting compensation for this position ranges from $181,021 to $212,965, complemented by potential incentive cash and stock opportunities based on eligibility. Compensation will be determined based on individual experience and job characteristics.

Benefit offerings may include medical, pharmacy, dental, and vision care, employee assistance programs (EAP), and a 401(K). Additional benefits encompass financial protection options such as short- and long-term disability, life insurance, and supplemental health insurance. Work-life balance programs include paid national holidays, optional holidays, global shutdown days between Christmas and New Year's, up to 120 hours of paid vacation, and sick leave. Other perks may include tuition reimbursement.