Director of Shared Antigen Cancer Vaccines Research

2 weeks ago

Cambridge, Massachusetts, United States Moderna Therapeutics Full time
About the Role

We are seeking a highly skilled and strategic Director of Shared Antigen Cancer Vaccines Research to join our Cancer Vaccines Research team, focusing on early pipeline programs.

Key Responsibilities
  • Lead the early discovery and preclinical validation of shared antigen cancer vaccine candidates, overseeing the translation of innovative scientific concepts into actionable clinical programs in close collaboration with a diverse array of internal teams.
  • Shape the overall strategy of the Cancer Vaccines portfolio and ensure that early-stage programs seamlessly progress into Moderna's broader oncology pipeline.
  • Collaborate with clinicians to translate research findings into actionable clinical strategies, work with translational experts to develop robust biomarker plans, and collaborate with CMC teams to ensure the timely manufacture of new vaccine candidates.
  • Author and review relevant IND modules in close collaboration with regulatory colleagues to ensure timely filing and responses to global regulatory agencies.
  • Develop and lead a high-performing team of scientists, fostering a culture of innovation, collaboration, and scientific excellence.
Requirements
  • PhD or MD/PhD in immunology, oncology, molecular biology, or a related field.
  • 10+ years of experience in cancer immunotherapy and/or vaccine development in industrial settings.
  • Proven leadership experience, with a history of leading successful research teams and early-stage discovery programs through IND filing.
  • Technical expertise to enable rigorous oversight of the generation and analysis of preclinical samples, such as genomic profiling, bulk and single cell RNA sequencing, multi-parameter flow/CyTOF panels/spectral flow cytometry, and MS-immunopeptidomics data.
  • Evidence of leveraging deep technical expertise in Immuno-Oncology to evaluate Mechanisms of Action and Resistance (MOA/MOR).
  • Experience in drafting and reviewing regulatory filings and working cross-functionally with clinical and regulatory teams.
  • Demonstrated ability to effectively manage and develop direct reports, manage multiple projects in a fast-paced environment with aggressive timelines, and build strong relationships with internal and external stakeholders.
Preferred Qualifications
  • Expertise developing mRNA-LNP therapeutics is highly desirable.
  • Experience in designing cancer vaccines comprised of shared antigens.
  • Familiarity with bioinformatics workflows with sufficient depth to enable strong thought partnership to analyze/understand large patient-derived datasets with computational colleagues.
  • Strong publication record, with the ability to present complex scientific data to both internal and external audiences.
About Moderna

Moderna is a leading biotechnology company that is pioneering the use of mRNA technology to develop transformative medicines for patients. We are committed to creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities.

We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S.

We are committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law.

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