Director of Shared Antigen Cancer Vaccines Research

1 day ago

Cambridge, Massachusetts, United States Moderna Therapeutics Full time
About the Role

Moderna Therapeutics is seeking a highly skilled and strategic Director of Shared Antigen Cancer Vaccines Research to join our Cancer Vaccines Research team. As a leader in the Cancer Vaccines team, you will help shape the overall strategy of the Cancer Vaccines portfolio and ensure that early-stage programs seamlessly progress into Moderna's broader oncology pipeline.

Key Responsibilities
  • Provide leadership and direction for early discovery programs, overseeing a team of scientists dedicated to evaluating new targets, optimizing immunogen designs, and demonstrating function in biochemical, cell-based, and preclinical models.
  • Contribute to envisioning, drafting, and critical review of regulatory documents, including INDs, supporting the advancement of early-stage clinical assets from the fast-emerging portfolio.
  • Lead, mentor, and develop a high-performing team of scientists, fostering a culture of innovation, collaboration, and scientific excellence.
  • Create and oversee an efficient research strategy, including milestone-driven, risk-mitigated experimental strategies.
  • Establish group goals, associated budgets, and set timelines for deliverables.
  • Build resilient, cross-functional relationships across the research and development organizations to enable robust thought partnership, execution of rigorous science, and efficient clinical development of our fast-expanding pipeline of medicines.
Requirements
  • PhD or MD/PhD in immunology, oncology, molecular biology, or a related field.
  • 10+ years of experience in cancer immunotherapy and/or vaccine development in industrial settings.
  • Proven leadership experience, with a history of leading successful research teams and early-stage discovery programs through IND filing.
  • Technical expertise to enable rigorous oversight of the generation and analysis of preclinical samples, such as genomic profiling, bulk and single-cell RNA sequencing, multi-parameter flow/CyTOF panels/spectral flow cytometry, and MS-immunopeptidomics data.
  • Evidence of leveraging deep technical expertise in Immuno-Oncology to evaluate Mechanisms of Action and Resistance (MOA/MOR).
  • Experience in drafting and reviewing regulatory filings and working cross-functionally with clinical and regulatory teams.
  • Demonstrated ability to effectively manage and develop direct reports.
  • Ability to manage multiple projects in a fast-paced environment with aggressive timelines.
  • Excellent interpersonal and communication skills, with a collaborative mindset and the ability to build strong relationships with internal and external stakeholders.
Preferred Qualifications
  • Expertise developing mRNA-LNP therapeutics is highly desirable.
  • Experience in designing cancer vaccines comprised of shared antigens.
  • Familiarity with bioinformatics workflows with sufficient depth to enable strong thought partnership to analyze/understand large patient-derived datasets with computational colleagues.
  • Strong publication record, with the ability to present complex scientific data to both internal and external audiences.
About Moderna Therapeutics

Moderna Therapeutics is a leading biotechnology company that is pioneering the use of mRNA technology to develop transformative medicines for patients. We are committed to creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities.

We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. We offer a comprehensive and innovative suite of benefits, including highly competitive medical, dental, and vision coverage options, flexible spending accounts, lifestyle spending accounts, family care benefits, and generous paid time off.

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