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Senior Research Associate, Quality Control
2 months ago
Company Background
Repertoire Immune Medicines is a pioneering biotechnology firm dedicated to harnessing the extraordinary capabilities of the human immune system for the treatment of cancer, autoimmune disorders, and infectious diseases. The foundation of our company is rooted in the understanding that the repertoire of T cell receptor (TCR)-antigen immune synapses is a significant opportunity for innovation in medical science. Our scientists have developed the DECODETM platform, which enables comprehensive characterization of TCR-antigen interactions, facilitating the creation of novel targeted immune therapies that can fundamentally alter the immune response to combat tumors or restore immune balance.
With operations in multiple locations, Repertoire is advancing a pipeline of DECODE-enabled immune therapies, including TCR bispecifics and mRNA cancer vaccines aimed at solid tumors, as well as mRNA tolerizing vaccines for autoimmune conditions.
Role Summary
We are looking for a dedicated Research Associate II/Senior Research Associate to join our Protein Engineering and Molecular Sciences Team. This role focuses on supporting the analytical and biophysical quality control (QC) of TCR bispecifics and MHC proteins, along with the development of analytical assays for transfer to manufacturing processes. The ideal candidate will possess hands-on experience with techniques such as size exclusion HPLC, SDS-PAGE, DSF, ELISA, and/or Octet/SPR.
The selected individual will be engaged in bench work to perform QC on TCR bispecifics and MHC proteins, conduct stability and developability assessments to prioritize therapeutic candidates, and create robust assays for seamless tech transfer to manufacturing partners. Responsibilities will include developing standard operating procedures (SOPs), generating and analyzing biochemical and biophysical data, and effectively presenting findings to management and team members.
Key Responsibilities
- Conduct analytical and biophysical QC of protein batches using techniques such as analytical SEC, PAGE, DSF, Octet/SPR, and ELISA.
- Develop and document reliable analytical assays for transfer to manufacturing partners.
- Perform comparability, developability, and accelerated stability assessments of lead therapeutic candidates.
- Capture primary data, establish and maintain SOPs, and document work in an Electronic Laboratory Notebook (ELN), ensuring records are current.
- Regularly present data to the Protein Sciences group and other multidisciplinary teams.
- Bachelor's or Master's degree in Biochemistry, Biology, Bioengineering, Immunology, or a related field.
- A minimum of 2 years of experience in an academic or biotech/pharmaceutical laboratory setting.
- Proficiency with HPLC systems and biochemical assays such as ELISA, SDS-PAGE, and DSF.
- Experience with Octet, SPR, or flow cytometry is advantageous.
- Strong organizational and communication skills, with a keen attention to detail.
- A collaborative mindset, thriving in a fast-paced and dynamic environment.
Repertoire is committed to social responsibility and fostering an inclusive culture. Just as the immune system's power lies in the diversity of T and B cells, our work benefits from the creativity and ingenuity of a diverse workforce. We actively pursue equity in all aspects of the work experience at Repertoire and are dedicated to addressing inequities and barriers in our society.
Repertoire is proud to be an Equal Opportunity Employer.
