Senior Scientist, Protein Conjugation Expert
14 hours ago
Fable Therapeutics is a biotechnology company that develops innovative biologics designed to overcome therapeutic index limitations. Our team is powered by state-of-the-art structure and sequence-based protein language models.
We are seeking a highly skilled Senior Scientist to join our team and establish our in-house protein conjugation capabilities. As an expert in biologics drug discovery, you will be responsible for conjugating antibodies and other protein-based candidate therapeutics using various chemistries and payloads.
Key Responsibilities- Design and evaluate different linker/payload structures and methods of protein conjugation
- Generate antibody and other protein conjugates using various chemistries and payloads
- Characterize protein conjugates in robust bioanalytical and in vitro assays
- Use liquid handlers and automation for high-throughput methods
- Binding assays based on SPR, BLI, and ELISA
- Careful documentation and record-keeping of scientific results
- Upload data to databases and LIMS systems
- Curation of data for ingestion and utilization by ML scientists
- Mentoring and training of junior scientists
- PhD/postdoc in Protein Engineering, Bioengineering, Protein Chemistry, or similar field, with 4+ years of industry experience in biologics discovery and protein science
- Proven track record in Antibody Drug Conjugates (ADCs) and other protein conjugation technologies
- Experience using various analytical instruments and methods for biophysical characterization of protein conjugates
- Familiarity with liquid-handling and high-throughput systems
- Committed to digital workflows and the lab of the future
- Ability to work efficiently in a close-knit team and deliver high-quality, reproducible data in a fast-paced environment
- Attentive to detail and careful experimentation
- Ability to take initiative and improve processes
- An excellent communicator and presenter of scientific data
- Passionate about the power of AI to transform biotherapeutics
- Focused on quantifiable results and data-driven decisions
- Collaborative and inclusive mindset
We are an equal opportunity employer and value diversity and inclusion. Fable Therapeutics provides an open, collegial, and friendly work environment where we empower people and provide them with opportunities to develop their long-term careers.
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