Nucleic Acid Chemistry Research Scientist

2 weeks ago


Redmond, Washington, United States GenScript Full time
About GenScript

GenScript Biotech Corporation is a leading global biotechnology group established in 2002, with a strong presence across North America, Europe, Greater China, and Asia Pacific. Our operations span four major sectors, leveraging our cutting-edge gene synthesis technology. These sectors include Life Science CRO services, enzyme and synthetic biology products, biologics development and manufacturing, and cell therapy solutions.

At GenScript, we are dedicated to our vision of becoming the most trusted biotech company, enhancing the health of both humanity and nature through innovative biotechnology solutions.

About GenScript ProBio

GenScript ProBio, a subsidiary of GenScript Biotech Corporation, specializes in providing comprehensive CDMO services from drug discovery to commercialization. We employ proactive strategies, professional solutions, and efficient processes in cell and gene therapy (CGT), vaccine development, biologics discovery, and antibody protein drug production to expedite drug development for our clients. Our extensive cell and gene therapy solutions encompass CMC for plasmid and viral vectors, supporting clinical and commercial manufacturing. Notably, we have facilitated numerous clinical approvals for CGT drugs, including mRNA vaccines and CAR-T therapies in China. We are also pioneers in GMP manufacturing, offering in vitro transcription (IVT) template linearized plasmids for mRNA vaccines.

Job Responsibilities:
  • Design and implement surface functionalizations for both metal and non-metal substrates in solid-phase oligonucleotide synthesis.
  • Utilize and select appropriate analytical techniques for thorough surface characterization.
  • Investigate methods to enhance surface stability and functional loading.
  • Develop methodologies for characterizing electrochemically synthesized oligonucleotide microarrays and pools.
  • Provide expertise in nucleic acid chemistry, particularly in phosphoramidite-based oligonucleotide synthesis.
  • Contribute to the advancement and refinement of electrochemical detritylation techniques.
  • Enhance all facets of CustomArray's array-based oligonucleotide synthesis platform.
  • Create electrochemical detection assays utilizing oligonucleotide microarrays.
  • Facilitate technology transfer to production teams and offer support for process improvements or troubleshooting.
  • Conduct statistical data analysis and effectively communicate findings.
Qualifications:
  • Ph.D. in Chemistry, Materials Science, Surface Science, Biochemistry, Bioengineering, or a related biomedical discipline, with a minimum of 4 years of experience in the pharmaceutical or biotech sectors.
  • Proven track record of success in product or assay development within an industrial setting.
  • Familiarity with electrochemistry and experience in electrochemical detection is highly desirable.
  • Hands-on experience with nucleoside, nucleotide, and solid-phase oligonucleotide synthesis.
  • Strong background in surface chemistry.


GenScript USA Inc./GenScript ProBio USA Inc. is an equal opportunity employer committed to fostering a diverse and inclusive workforce. We uphold a drug-free workplace policy.

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