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Nucleic Acid Chemistry Research Scientist
2 months ago
GenScript Biotech Corporation is a prominent global biotechnology group, established in 2002, with a strong presence across North America, Europe, Greater China, and Asia Pacific. The company operates in four major sectors, leveraging its leading gene synthesis technology, including Life Science CRO services, enzyme and synthetic biology products, biologics development and manufacturing, and cell therapy.
GenScript is dedicated to its vision of becoming the most dependable biotech company globally, enhancing human and environmental health through innovative biotechnology solutions.
About GenScript ProBio
GenScript ProBio, a subsidiary of GenScript Biotech Corporation, offers comprehensive CDMO services from drug discovery to commercialization. The company employs proactive strategies, professional solutions, and efficient processes in cell and gene therapy (CGT), vaccine development, biologics discovery, and antibody protein drug production to expedite drug development for its clients. GenScript ProBio's total solution for cell and gene therapy includes CMC for plasmid and viral vectors for IND filing, as well as clinical and commercial manufacturing. The subsidiary supports the highest number of clinical approvals for CGT drugs, including mRNA vaccines and CAR-T therapies in China. It is also recognized for being the first GMP manufacturing platform to provide in vitro transcription (IVT) template linearized plasmids for mRNA vaccines, assisting numerous global enterprises in achieving clinical approvals. Additionally, GenScript ProBio boasts a stable and high-yield viral vector platform.
Job Scope:
We are in search of a skilled Scientist with a diverse background, particularly in oligonucleotide synthesis, surface functionalization, organic and bioorganic synthesis, and molecular biology. Ideal candidates will also possess knowledge and experience in biosensors, electrochemistry, and nucleic acid chemistry. This role will involve research and collaboration with scientists and engineers to enhance the company's proprietary semiconductor DNA synthesis technology and develop various diagnostic applications.
Location: Remote
Responsibilities:
- Develop surface functionalizations for various substrates in solid-phase oligonucleotide synthesis.
- Select and apply analytical techniques for surface characterization.
- Investigate methods to improve surface stability and functional loading.
- Establish characterization methodologies for analyzing electrochemically synthesized oligonucleotide microarrays and pools.
- Provide expertise in nucleic acid chemistry, particularly in phosphoramidite-based oligonucleotide synthesis.
- Contribute to the development and refinement of electrochemical detritylation techniques.
- Enhance all aspects of the array-based oligonucleotide synthesis platform.
- Develop electrochemical detection assays for oligonucleotide microarrays.
- Facilitate technology transfer to the production team and offer support for process improvements or troubleshooting.
- Conduct statistical data analysis and present findings effectively.
- Ph.D. in Chemistry, Materials Science, Surface Science, Biochemistry, Bioengineering, or a related biomedical field with a minimum of 4 years of experience in pharmaceutical, biotech, or related industries.
- Proven track record of success in product or assay development.
- Familiarity with electrochemistry and experience in electrochemical detection is preferred.
- Experience in nucleoside, nucleotide, and solid-phase oligonucleotide synthesis.
- Knowledge of surface chemistry.
Equal Opportunity Employer: GenScript USA Inc./GenScript ProBio USA Inc. is an equal opportunity/affirmative action employer committed to fostering a diverse and inclusive workforce. The company ensures equal employment opportunities without discrimination or harassment based on race, color, religion, sex, sexual orientation, gender identity or expression, age, disability, national origin, marital status, genetic information, citizenship status, or veteran status.
