DMPK Project Director
2 weeks ago
We are seeking a highly skilled DMPK Project Leader to join our team at Beacon Hill. As a key member of our discovery team, you will be responsible for providing technical and scientific expertise for ADME profiling and interpretation of data.
Key Responsibilities:
- Represent the DMPK function on cross-functional discovery teams and provide technical and scientific expertise for ADME profiling and interpretation of data.
- Define strategy for in vitro/in vivo DMPK and DDI risk assessment for drug candidates.
- Strategically design and lead ADME/PK studies, critically analyze and interpret data, identify issues, and help overcome technical challenges.
- Coordinate and interact with matrix project team members for planning and executing DMPK-related activities.
- Collaborate with PK/PD modelers to establish PK/PD correlations and guide preclinical study design.
- Contribute to the selection of preclinical tox species and toxicokinetic plan to support IND.
- Support human dose projections based on preclinical data to guide candidate selection.
- Author ADME/DMPK sections of regulatory documents (e.g., IND/IB).
- Contribute to the development of functional processes and procedures focused on CRO interactions and organizational efficiency.
- Conduct scientific presentations to senior management, project teams, and internal/external collaborators.
- Provide operational oversight for quality and performance of DMPK activities, including interactions with CROs and external project support.
- Contribute to the selection and qualification of CROs and vendors.
Basic Qualifications:
- Ph.D. in pharmaceutical science, biochemistry, or related scientific discipline with 7+ years of experience or MS/BS with 10+ years of relevant experience.
- 5+ years of experience leading the DMPK function on project teams, particularly in discovery and early development.
- Extensive knowledge of drug metabolism, PK, and relevant analytical techniques.
- Strong understanding of small molecule drug discovery workflow.
- Hands-on experience conducting, troubleshooting, and summarizing in vitro and in vivo ADME/DMPK studies.
- Familiarity with regulatory guidelines and requirements related to DMPK in drug development.
- Demonstrated DMPK skills through high-quality peer-reviewed publications.
- Experience in outsourcing and external oversight of nonclinical DMPK/ADME studies.
What We Offer:
- A dynamic and collaborative work environment.
- Opportunities for professional growth and development.
- A competitive salary and benefits package.
-
DMPK Project Specialist Director
4 days ago
Cambridge, Massachusetts, United States GSK Full timeUnlock Your Potential in DMPK Project LeadershipWe are seeking a highly skilled and experienced DMPK Project Specialist Director to join our team at GSK. As a key member of our Development DMPK Project Specialist group, you will play a critical role in designing and delivering the DMPK strategy to ensure project progression from FTIH through to regulatory...
-
Senior Director, DMPK Expert
1 week ago
Cambridge, Massachusetts, United States Bicycle Therapeutics Full timeJob Title: Senior Director, DMPKBicycle Therapeutics is seeking a highly experienced Senior Director to lead our Drug Metabolism and Pharmacokinetics (DMPK) team. As a key member of our Quantitative Pharmacology group, you will be responsible for providing scientific leadership across all stages of our portfolio, from target identification to candidate...
-
Senior Director, DMPK Expert
2 weeks ago
Cambridge, Massachusetts, United States Bicycle Therapeutics Full timeJob Title: Senior Director, DMPKBicycle Therapeutics is a clinical-stage pharmaceutical company seeking a highly skilled Senior Director to lead our Drug Metabolism and Pharmacokinetics (DMPK) team. As a key member of our Quantitative Pharmacology group, you will be responsible for providing scientific leadership and expertise in DMPK across all stages of...
-
DMPK Project Leader
1 week ago
Cambridge, Massachusetts, United States Beacon Hill Full timeDMPK Project LeaderBeacon Hill is seeking a highly skilled DMPK Project Leader to join our team. As a key member of our discovery team, you will be responsible for leading cross-functional teams and providing technical and scientific expertise for ADME profiling and interpretation of data.Key Responsibilities:Represent the DMPK function on cross-functional...
-
Associate Director, DMPK
3 days ago
Cambridge, Massachusetts, United States Atavistik Bio Full timeAbout Atavistik BioAtavistik Bio is a pioneering biotech company dedicated to unlocking the potential of allosteric precision therapeutics. Our mission is to address serious unmet patient needs by harnessing the power of our proprietary screening technology and AI-enabled drug discovery platform.Job SummaryWe are seeking a highly skilled Associate Director,...
-
Associate Director, DMPK Lead
1 week ago
Cambridge, Massachusetts, United States Atavistik Bio Full timeJob SummaryWe are seeking a highly skilled Associate Director, DMPK to join our development group at Atavistik Bio. As a key member of our scientific leadership team, you will be responsible for designing, executing, and interpreting non-clinical DMPK and toxicology studies to support the progression of therapies from late discovery through first in human...
-
DMPK Specialist
7 days ago
Cambridge, Massachusetts, United States Beacon Hill Life Sciences - Boston Full timeJob OpportunityWe are seeking a highly skilled DMPK Contractor to join our team at Beacon Hill Life Sciences - Boston. As a key member of our research and development team, you will play a crucial role in supporting DMPK activity in various projects.Key Responsibilities:Prepare, review, and data QC of GLP/non-GLP-related documents generated internally or...
-
Principal DMPK Scientist
1 week ago
Cambridge, Massachusetts, United States Newton Colmore Full timeExciting Opportunity in Biotech ResearchNewton Colmore is proud to partner with a leading biotech company in Cambridge, MA, seeking a highly skilled DMPK and ADME expert to join their research team. This is an exceptional opportunity to make a meaningful impact in the development of novel medicines.Key Responsibilities:Represent DMPK across the company's...
-
Cambridge, Massachusetts, United States Bicycle Therapeutics Full timeJob Title: Associate Director of Drug Metabolism and PharmacokineticsBicycle Therapeutics is a clinical-stage pharmaceutical company developing innovative medicines for underserved diseases. We are seeking an experienced Associate Director of Drug Metabolism and Pharmacokinetics (DMPK) to join our team.Key Responsibilities:Design and execute non-clinical...
-
Cambridge, Massachusetts, United States Bicycle Therapeutics Full timeJob DescriptionThe Associate Director of Drug Metabolism and Pharmacokinetics (DMPK) plays a pivotal role in the success of our drug development pipeline at Bicycle Therapeutics. Reporting to the Vice President of Quantitative Pharmacology, this individual will be responsible for representing DMPK, designing and executing non-clinical studies in support of...
-
Cambridge, Massachusetts, United States Recludix Pharma Full timeJob Summary:We are seeking an experienced leader to build our capabilities in support of our small molecule portfolio in inflammation and oncology through IND and development. The candidate will have strategic and scientific oversight of our small molecule discovery and development portfolio and will manage the in vitro and in vivo PK, ADME and bioanalytical...
-
Senior Scientist PK Sciences Oncology
3 weeks ago
Cambridge, Massachusetts, United States Novartis Group Companies Full timeJob Description SummaryJob Title: Principal/Senior Principal Scientist PK Sciences OncologyJob Summary: We are seeking an enthusiastic and motivated PK Sciences project team representative to develop and implement DMPK and/or clinical pharmacology strategies to support the pursuit of transformative new medicines from early discovery through late clinical...
-
Lead Scientist
4 weeks ago
Cambridge, Massachusetts, United States Novartis Farmacutica Full timeAbout the RoleWe are seeking a highly skilled and experienced Senior Research Scientist to join our team at Novartis Farmacutica. As a key member of our Pharmacokinetics and Pharmacodynamics team, you will be responsible for developing and implementing discovery DMPK and/or translational strategies to support the pursuit of transformative new medicines from...
-
Senior Scientist, Molecular Bioanalytics Expert
4 weeks ago
Cambridge, Massachusetts, United States Editas Medicine Full timeJob SummaryEditas Medicine is seeking a highly skilled Senior Scientist to join our DMPK, Nonclinical Safety and Translational Sciences (DSTS) team. As a key member of our team, you will be responsible for supporting ADME, biodistribution, PK/PD and bioanalytical activities.Key ResponsibilitiesDevelop and Execute Molecular Bioanalytical Assays: Establish and...
-
Strategic Project Director
3 weeks ago
Cambridge, Massachusetts, United States GlaxoSmithKline Full timeGeneral Project Management DirectorAre you a seasoned project management professional looking to drive change and lead key activities in a dynamic environment? We are seeking a General Project Management Director to join our team at GlaxoSmithKline.Key Responsibilities:Support the alignment and delivery of the business strategy in line with the overarching...
-
Lead Scientist
1 month ago
Cambridge, Massachusetts, United States Novartis Farmacéutica Full timePosition Overview:We are looking for a dedicated and skilled Lead Scientist in the field of Oncology Pharmacokinetics to join our team at Novartis Farmacéutica. This role is essential in advancing our mission to develop innovative therapies that improve patient outcomes.Role Summary:The Lead Scientist will be a key member of the PK Sciences team,...
-
Director of Special Projects
1 week ago
Cambridge, Massachusetts, United States Harvard University Full timeJob SummaryThe Director of Special Projects at Harvard University's Institute of Politics is responsible for conceiving and directing the development and implementation of high-profile political events and conferences. This includes overseeing large-scale conferences, managing existing collaborations with national organizations, and developing new...
-
Research Associate Molecular Bioanalytics
2 weeks ago
Cambridge, Massachusetts, United States Editas Medicine Full timeJob Title: Research Associate, Molecular BioanalyticsAbout the Role:Editas Medicine is seeking a highly motivated and creative Research Associate to join our DMPK, Nonclinical Safety and Translational Sciences (DSTS) team. In this role, you will be responsible for supporting ADME, biodistribution, PK/PD and bioanalytical activities.Key...
-
Project Director
2 weeks ago
Cambridge, Massachusetts, United States Talent Groups Full timeProject ManagerWe are seeking a highly skilled and experienced Project Manager to drive success through our commercial operations and analytics functions. This role will play a crucial part in building and leading high-performing teams, developing and implementing commercial strategies, and delivering results-driven projects.Key Responsibilities:Project...
-
Principal Scientist
4 weeks ago
Cambridge, Massachusetts, United States Novartis Group Companies Full timeJob SummaryWe are seeking an experienced Senior Principal Scientist or Principal Scientist to join our Oncology Research and Development team at Novartis Group Companies. The successful candidate will be responsible for developing and implementing pharmacokinetics and clinical pharmacology strategies to support the development of innovative medicines.Key...