Senior/Principal Scientist, Biology

2 days ago


Cambridge, United States Crossbow Therapeutics, Inc Full time

Crossbow Therapeutics is looking for a Senior Scientist/Principal Scientist, Biology


Crossbow Therapeutics, Inc., is a biotechnology company determined to improve the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. The company’s T-Bolt™ therapies are next-generation, easily assembled immunotherapies directed with high precision at previously unreachable cancer cell targets. Crossbow’s efficient and selective approach is designed to target the entire universe of cancer proteins, dramatically expanding the potential of antibody therapy to address many types of cancer.


Join us on our bold quest to broaden the benefits of immunotherapy and improve the lives of people living with cancer. For more information, visit us at .


About The Opportunity


This is an opportunity to be part of an exciting and growing Biology team. The level of the position will be commensurate with the candidate’s education and industry experience.


Key Responsibilities:


  • Lead one or more programs from discovery through DC nomination.
  • Independently work to generate, critically analyze and interpret data with scientific rigor and an open mind.
  • Lead the design and execution of immune cell-based experiments.
  • Perform multiparameter flow cytometry-based experiments.
  • Work collaboratively with scientists and research associates within and across teams to accomplish program goals.
  • Thorough documentation of experiments and communication of results with scientific team members and stakeholders.
  • Presentation of program strategy and progress to research leadership team and at external scientific meetings.
  • Contribute to maintaining a creative and safe laboratory environment.
  • Manage 1 or more direct reports.


Preferred qualifications and past experience:


  • Ph.D. in Immunology, Cancer Biology or related field. More than 3+ years of experience in either an academic or industrial setting. B.S./M.S. with more than 8+ years of experience in Immunology, preferably in Immuno-oncology.
  • The ideal candidate would have a strong background in tumor Immunology with a deep understanding of how cytotoxic T cells recognize and eliminate target cells. Familiarity with TCR/HLA biology preferred.
  • Experience with techniques related to T cell immunology and tumor immunotherapy, such as T cell dependent cellular cytotoxicity assays, cytokine analysis, and flow cytometry (including FlowJo data analysis)
  • Ability to thrive in a highly collaborative fast-moving small biotech environment.
  • Pro-active problem solver, strong interpersonal skills, highly collaborative, and outstanding communication skills.
  • Ability to present and explain research to a wide variety of audiences.
  • A creative, flexible and self-motivated individual.
  • The candidate must have a passion for conducting experiments and being part of a strong lab team.
  • Management experience is a plus and may position the candidate to build and lead a team of scientists as the company grows.


To apply for this role: Send your resume directly to apply@crossbowtx.com


Location: This position is full-time, on site at Crossbow’s Cambridge, MA office. Crossbow Therapeutics is located at 1030 Massachusetts Ave. Suite 210, Cambridge, Massachusetts.



  • Cambridge, Massachusetts, United States Crossbow Therapeutics, Inc Full time

    Crossbow Therapeutics, Inc. is a biotechnology company dedicated to improving the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. Our T-BoltTM therapies are next-generation, easily assembled immunotherapies directed with high precision at previously unreachable cancer cell targets. Our approach...


  • Cambridge, Massachusetts, United States Crossbow Therapeutics, Inc Full time

    About the OpportunityCrossbow Therapeutics, Inc. is a biotechnology company dedicated to revolutionizing cancer treatment through innovative immunotherapies. We are seeking a highly skilled Senior Scientist/Principal Scientist, Biology to join our dynamic team.Key Responsibilities:Lead programs from discovery through DC nomination, driving scientific rigor...


  • Cambridge, Massachusetts, United States Crossbow Therapeutics, Inc Full time

    About the OpportunityCrossbow Therapeutics, Inc. is a biotechnology company dedicated to improving the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. Our T-BoltTM therapies are next-generation, easily assembled immunotherapies directed with high precision at previously unreachable cancer cell...


  • Cambridge, United States Crossbow Therapeutics, Inc Full time

    Crossbow Therapeutics is looking for a Senior Scientist/Principal Scientist, Biology Crossbow Therapeutics, Inc., is a biotechnology company determined to improve the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. The company’s T-Bolt™ therapies are next-generation, easily assembled...


  • Cambridge, United States Crossbow Therapeutics, Inc Full time

    Crossbow Therapeutics is looking for a Senior Scientist/Principal Scientist, Biology Crossbow Therapeutics, Inc., is a biotechnology company determined to improve the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. The company’s T-Bolt™ therapies are next-generation, easily assembled...


  • cambridge, United States Crossbow Therapeutics, Inc Full time

    Crossbow Therapeutics is looking for a Senior Scientist/Principal Scientist, Biology Crossbow Therapeutics, Inc., is a biotechnology company determined to improve the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. The company’s T-Bolt™ therapies are next-generation, easily assembled...


  • Cambridge, Massachusetts, United States Novartis Group Companies Full time

    About the Role:The Novartis Group of Companies is seeking a highly skilled and experienced Senior Principal Scientist to join our team in Cambridge, MA. As a key member of our dynamic and multi-disciplinary team, you will play a critical role in developing and applying in vivo models to evaluate novel cancer therapies in the early-stage drug discovery...


  • Cambridge, Massachusetts, United States BlueRock Therapeutics Full time

    Job Title: Senior Scientist, PSC BiologyJob Summary:BlueRock Therapeutics is seeking a highly skilled Senior Scientist, PSC Biology to lead the development, testing, and implementation of novel NGS sequencing technologies to characterize human pluripotent stem cells (hPSCs) and their differentiated progeny at the molecular, (epi-) genomic level.Key...


  • Cambridge, Massachusetts, United States Novartis Group Companies Full time

    Job Description SummarySenior Principal Scientist, PharmacologyThis is a lab head-based position where the ideal candidate will lead the design and execution of anti-tumor efficacy and PK/PD studies that evaluate drug candidates in CDX, PDX, and syngeneic models.Key Responsibilities:Design and execute pre-clinical in vivo studies to explore novel hypotheses,...


  • Cambridge, Massachusetts, United States Flagship Pioneering Full time

    Company Overview:Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. With a proven track record of success, Flagship has originated and fostered over 100 scientific ventures, resulting in over $90 billion in aggregate...


  • Cambridge, Massachusetts, United States Flagship Pioneering Full time

    Company Overview:Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Our mission is to leverage advanced biological and computational platforms to discover breakthroughs in detection of and intervention against the...


  • Cambridge, Massachusetts, United States Flagship Pioneering Full time

    Company Overview:Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. With a strong focus on innovation and entrepreneurship, Flagship has originated and fostered over 100 scientific ventures, resulting in over $90...


  • cambridge, United States GC Therapeutics Full time

    Scientist/Senior Scientist - In Vivo Biology (Neuroscience)Company OverviewGC Therapeutics is the first genome-wide cell landscape exploration company using an integrated synthetic biology and AI-driven platform for cell programming. Its patent-pending and proprietary pluripotent stem cell differentiation technology platform TFome™ was developed in...


  • Cambridge, United States GC Therapeutics Full time

    Scientist/Senior Scientist - In Vivo Biology (Neuroscience)Company OverviewGC Therapeutics is the first genome-wide cell landscape exploration company using an integrated synthetic biology and AI-driven platform for cell programming. Its patent-pending and proprietary pluripotent stem cell differentiation technology platform TFome™ was developed in...


  • Cambridge, United States GC Therapeutics Full time

    Scientist/Senior Scientist - In Vivo Biology (Neuroscience)Company OverviewGC Therapeutics is the first genome-wide cell landscape exploration company using an integrated synthetic biology and AI-driven platform for cell programming. Its patent-pending and proprietary pluripotent stem cell differentiation technology platform TFome™ was developed in...


  • Cambridge, United States GC Therapeutics Full time

    Scientist/Senior Scientist - In Vivo Biology (Neuroscience)Company OverviewGC Therapeutics is the first genome-wide cell landscape exploration company using an integrated synthetic biology and AI-driven platform for cell programming. Its patent-pending and proprietary pluripotent stem cell differentiation technology platform TFome™ was developed in...


  • Cambridge, Massachusetts, United States Montai Therapeutics Full time

    Immunologist Opportunity at Montai TherapeuticsMontai Therapeutics is a pioneering biotechnology company dedicated to transforming healthcare and sustainability through innovative technologies. We are seeking an experienced Immunologist to join our Early Discovery Biology team as a Principal Scientist.About the RoleThis is an exciting opportunity to drive...


  • Cambridge, Massachusetts, United States Flagship Ventures Full time

    Transforming Drug Discovery with Flagship PioneeringAt Flagship Pioneering, we are dedicated to transforming drug discovery by leveraging deep biological insights and cutting-edge scientific innovations. Our mission is to deliver breakthrough therapies that address critical unmet medical needs.Job SummaryWe are seeking an experienced and highly motivated...


  • Cambridge, Massachusetts, United States GSK LLP Full time

    Job Title: Principal Scientist UpstreamGSK is seeking a highly motivated and experienced Principal Scientist Upstream to join our mRNA Drug Substance team in Cambridge, MA. As a key member of our team, you will play a critical role in shaping our mRNA vaccine platforms to accelerate the development of new vaccine candidates.Key Responsibilities:Design,...


  • Cambridge, Massachusetts, United States Flagship Ventures Full time

    Immunology Research ScientistFlagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. We are seeking a highly skilled PhD level Principal Scientist with proven experience in immunology and preclinical research to join our team.Key...