Scientist/Senior Scientist

4 weeks ago

cambridge, United States GC Therapeutics Full time

Scientist/Senior Scientist - In Vivo Biology (Neuroscience)


Company Overview

GC Therapeutics is the first genome-wide cell landscape exploration company using an integrated synthetic biology and AI-driven platform for cell programming. Its patent-pending and proprietary pluripotent stem cell differentiation technology platform TFome™ was developed in Professor George Church’s lab, a pioneer in synthetic biology, and allows for the development of unique cell therapies with significantly streamlined manufacturing, improved cell quality, efficiency and speed. GC Therapeutics is based in Cambridge, MA. For additional information, please visit www.gc-tx.com.


Job Purpose

GC Therapeutics is seeking a talented and highly motivated scientist for our neuroscience program. This role will involve bringing a new class of cellular therapies to patients using GCTx’s Human TFome™ platform, a synthetic biology-driven technology to differentiate human stem cells. The candidate will have strong expertise in in vivo studies using preclinical animal models of disease. Initially, this candidate will design experiments to assess GCTx’s cell therapies in small animal models and supervise the execution of these experiments by CROs and collaborators. The role will involve setting up an in-house vivarium. The candidate will be responsible for animal handling and personally designing and executing animal studies.

Duties and Responsibilities


General Laboratory Roles:

  • Responsible for experimental design, data generation, analysis, and communication of results to supervisor, and team members.
  • Maintain a detailed laboratory journal, summarize results and create presentations for internal group meetings.
  • Exemplify scientific curiosity and deep expertise with relevant literature and cutting-edge technologies to advance research directions.
  • Work with other members of the research team and within GCTx to accomplish company goals.
  • Follow all safe laboratory practices and company policies.


Essential Qualifications:

  • Ph.D. degree in neuroscience, cell biology, or related discipline and 5+ years of laboratory work experience in academia or industry.
  • Expertise in creating packages for preclinical in vivo studies for IND applications.
  • Oversee GLP and non-GLP in vivo (e.g. rodent and non-human primate) studies internally or out-sourced from lead selection screening through lead candidate IND-enabling work.
  • Maintain and manage relationships with preclinical CROs, serving as the primary liaison between the company and external vendors.
  • Support regulatory writing of nonclinical sections of regulatory submissions.
  • Stereotaxic surgery expertise in animals (e.g. rodents) for mono- or multifocal injections.
  • CNS tissue processing and immunohistochemistry.
  • Strong work ethic with the ability to perform tasks independently and manage both junior staff and external collaborators.
  • Proficient in analysis, presentation and documentation of scientific data as well as preparation of scientific reports.
  • Strong project and time management skills.
  • Ability to work in a laboratory environment approximately 75% of the time, including some weekend hours.


Additional Preferred Qualifications:

  • Proven track record and strong publications in neuroscience, animal work and preclinical studies in Industry.
  • Expertise in cell therapy, and routes of administration for preclinical animal models of disease.


Equal Opportunity Workplace: GC Therapeutics is an equal opportunity employer. We provide equal employment opportunities to all applicants for employment and existing employees without regard to ancestry, national origin, place of birth, race, color, gender, sexual orientation, marital status, pregnancy, religion, age, disability, gender identity, results of genetic testing, service in the military or otherwise to the full extent of all federal, state and local laws. GC Therapeutics’ equal employment opportunity policy applies to all terms and conditions of recruiting, hiring, placement, training, compensation, transfer, leave of absence, employment, promotion, layoff and termination of employment.

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