Senior/Principal Scientist, Biology

3 days ago


Cambridge, Massachusetts, United States Crossbow Therapeutics, Inc Full time

About the Opportunity

Crossbow Therapeutics, Inc. is a biotechnology company dedicated to improving the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. Our T-BoltTM therapies are next-generation, easily assembled immunotherapies directed with high precision at previously unreachable cancer cell targets.

We are seeking a highly skilled Senior/Principal Scientist, Biology to join our growing Biology team. The successful candidate will have a strong background in tumor Immunology and a deep understanding of how cytotoxic T cells recognize and eliminate target cells.

Key Responsibilities:

  • Lead one or more programs from discovery through DC nomination.
  • Independently work to generate, critically analyze and interpret data with scientific rigor and an open mind.
  • Lead the design and execution of immune cell-based experiments.
  • Perform multiparameter flow cytometry-based experiments.
  • Work collaboratively with scientists and research associates within and across teams to accomplish program goals.
  • Thorough documentation of experiments and communication of results with scientific team members and stakeholders.
  • Presentation of program strategy and progress to research leadership team and at external scientific meetings.
  • Contribute to maintaining a creative and safe laboratory environment.
  • Manage 1 or more direct reports.

Preferred qualifications and past experience:

  • Ph.D. in Immunology, Cancer Biology or related field. More than 3+ years of experience in either an academic or industrial setting. B.S./M.S. with more than 8+ years of experience in Immunology, preferably in Immuno-oncology.
  • The ideal candidate would have a strong background in tumor Immunology with a deep understanding of how cytotoxic T cells recognize and eliminate target cells. Familiarity with TCR/HLA biology preferred.
  • Experience with techniques related to T cell immunology and tumor immunotherapy, such as T cell dependent cellular cytotoxicity assays, cytokine analysis, and flow cytometry (including FlowJo data analysis).
  • Ability to thrive in a highly collaborative fast-moving small biotech environment.
  • Pro-active problem solver, strong interpersonal skills, highly collaborative, and outstanding communication skills.
  • Ability to present and explain research to a wide variety of audiences.
  • A creative, flexible and self-motivated individual.
  • The candidate must have a passion for conducting experiments and being part of a strong lab team.
  • Management experience is a plus and may position the candidate to build and lead a team of scientists as the company grows.

Location: This position is full-time, on site at Crossbow's Cambridge, MA office.



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