Scientist/Senior Scientist

2 months ago

Cambridge, United States GC Therapeutics Full time

Scientist/Senior Scientist - In Vivo Biology (Neuroscience)


Company Overview

GC Therapeutics is the first genome-wide cell landscape exploration company using an integrated synthetic biology and AI-driven platform for cell programming. Its patent-pending and proprietary pluripotent stem cell differentiation technology platform TFome™ was developed in Professor George Church’s lab, a pioneer in synthetic biology, and allows for the development of unique cell therapies with significantly streamlined manufacturing, improved cell quality, efficiency and speed. GC Therapeutics is based in Cambridge, MA. For additional information, please visit www.gc-tx.com.


Job Purpose

GC Therapeutics is seeking a talented and highly motivated scientist for our neuroscience program. This role will involve bringing a new class of cellular therapies to patients using GCTx’s Human TFome™ platform, a synthetic biology-driven technology to differentiate human stem cells. The candidate will have strong expertise in in vivo studies using preclinical animal models of disease. Initially, this candidate will design experiments to assess GCTx’s cell therapies in small animal models and supervise the execution of these experiments by CROs and collaborators. The role will involve setting up an in-house vivarium. The candidate will be responsible for animal handling and personally designing and executing animal studies.

Duties and Responsibilities


General Laboratory Roles:

  • Responsible for experimental design, data generation, analysis, and communication of results to supervisor, and team members.
  • Maintain a detailed laboratory journal, summarize results and create presentations for internal group meetings.
  • Exemplify scientific curiosity and deep expertise with relevant literature and cutting-edge technologies to advance research directions.
  • Work with other members of the research team and within GCTx to accomplish company goals.
  • Follow all safe laboratory practices and company policies.


Essential Qualifications:

  • Ph.D. degree in neuroscience, cell biology, or related discipline and 5+ years of laboratory work experience in academia or industry.
  • Expertise in creating packages for preclinical in vivo studies for IND applications.
  • Oversee GLP and non-GLP in vivo (e.g. rodent and non-human primate) studies internally or out-sourced from lead selection screening through lead candidate IND-enabling work.
  • Maintain and manage relationships with preclinical CROs, serving as the primary liaison between the company and external vendors.
  • Support regulatory writing of nonclinical sections of regulatory submissions.
  • Stereotaxic surgery expertise in animals (e.g. rodents) for mono- or multifocal injections.
  • CNS tissue processing and immunohistochemistry.
  • Strong work ethic with the ability to perform tasks independently and manage both junior staff and external collaborators.
  • Proficient in analysis, presentation and documentation of scientific data as well as preparation of scientific reports.
  • Strong project and time management skills.
  • Ability to work in a laboratory environment approximately 75% of the time, including some weekend hours.


Additional Preferred Qualifications:

  • Proven track record and strong publications in neuroscience, animal work and preclinical studies in Industry.
  • Expertise in cell therapy, and routes of administration for preclinical animal models of disease.


Equal Opportunity Workplace: GC Therapeutics is an equal opportunity employer. We provide equal employment opportunities to all applicants for employment and existing employees without regard to ancestry, national origin, place of birth, race, color, gender, sexual orientation, marital status, pregnancy, religion, age, disability, gender identity, results of genetic testing, service in the military or otherwise to the full extent of all federal, state and local laws. GC Therapeutics’ equal employment opportunity policy applies to all terms and conditions of recruiting, hiring, placement, training, compensation, transfer, leave of absence, employment, promotion, layoff and termination of employment.

  • Senior Research Scientist

    3 weeks ago

    Cambridge, Massachusetts, United States Mass General Brigham Full time

    Job SummaryWe are seeking a highly skilled Senior Research Scientist to join our team at Mass General Brigham. The successful candidate will have a strong background in medical device interoperability and cybersecurity, with a proven track record of leading research projects and managing technical staff.Key ResponsibilitiesResearch and Development: The...

  • Senior Scientist, Biology Lead

    4 weeks ago

    Cambridge, Massachusetts, United States Crossbow Therapeutics, Inc Full time

    About the OpportunityCrossbow Therapeutics, Inc. is a biotechnology company dedicated to revolutionizing cancer treatment through innovative immunotherapies. We are seeking a highly skilled Senior Scientist/Principal Scientist, Biology to join our dynamic team.Key Responsibilities:Lead programs from discovery through DC nomination, driving scientific rigor...

  • Senior/Principal Scientist, Biology

    4 weeks ago

    Cambridge, Massachusetts, United States Crossbow Therapeutics, Inc Full time

    Crossbow Therapeutics, Inc. is a biotechnology company dedicated to improving the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. Our T-BoltTM therapies are next-generation, easily assembled immunotherapies directed with high precision at previously unreachable cancer cell targets. Our approach...

  • Senior Scientist, Immunology Discovery

    4 weeks ago

    cambridge, United States Simcere Zaiming Full time

    Senior Scientist (Preclinical-Autoimmunity)Simcere is seeking a Senior Scientist to join our preclinical team to help advance our discovery programs evaluating novel immune regulatory therapies to treat autoimmune and inflammatory diseases. The successful applicant will have a strong background and track record in designing, executing, analyzing, and...

  • Senior Scientist, Immunology Discovery

    1 month ago

    Cambridge, United States Simcere Zaiming Full time

    Senior Scientist (Preclinical-Autoimmunity)Simcere is seeking a Senior Scientist to join our preclinical team to help advance our discovery programs evaluating novel immune regulatory therapies to treat autoimmune and inflammatory diseases. The successful applicant will have a strong background and track record in designing, executing, analyzing, and...

  • Senior Data Scientist

    3 weeks ago

    Cambridge, Massachusetts, United States BioSpace, Inc. Full time

    Job Title: Senior Data ScientistJob Summary:We are seeking a highly skilled Senior Data Scientist to join our team at BioSpace, Inc. in Cambridge, MA. As a Senior Data Scientist, you will be responsible for leading complex data analysis projects, developing and implementing machine learning models, and providing data-driven insights to inform business...

  • Senior Research Scientist

    3 weeks ago

    Cambridge, Massachusetts, United States Nava Therapeutics Full time

    Senior Scientist – Lipid Nanoparticle (LNP) DeliveryNava Therapeutics is a rapidly growing, early-stage company that is developing cutting-edge, high-throughput technologies to discover and advance novel delivery strategies for nucleic acid therapeutics. Our mission is to make a difference in the daily lives of patients through our clinical impact.We offer...

  • Scientist/Senior Scientist

    4 weeks ago

    cambridge, United States GC Therapeutics Full time

    Scientist / Senior Scientist – Computational BiologyCompany OverviewGC Therapeutics is the first genome-wide cell landscape exploration company using an integrated synthetic biology and AI-driven platform for cell programming. Its patent-pending and proprietary pluripotent stem cell differentiation technology platform TFome™ was developed in Professor...

  • Scientist/Senior Scientist

    1 week ago

    Cambridge, United States GC Therapeutics Full time

    Scientist / Senior Scientist – Computational BiologyCompany OverviewGC Therapeutics is the first genome-wide cell landscape exploration company using an integrated synthetic biology and AI-driven platform for cell programming. Its patent-pending and proprietary pluripotent stem cell differentiation technology platform TFome™ was developed in Professor...

  • Senior Scientist, II

    3 weeks ago

    Cambridge, Massachusetts, United States AbbVie Full time

    Job OpportunityWe are seeking a highly motivated and talented Senior Scientist II to join our Molecular Profiling and Drug Delivery (MPDD) function within the Small Molecule CMC organization.About the RoleThis role will serve as an MPDD project leader on discovery programs, leading CMC developability assessment for emerging molecules on small molecule...

  • Scientist/Senior Scientist

    4 weeks ago

    cambridge, United States GC Therapeutics Full time

    Scientist/Senior Scientist - In Vivo Biology (Neuroscience)Company OverviewGC Therapeutics is the first genome-wide cell landscape exploration company using an integrated synthetic biology and AI-driven platform for cell programming. Its patent-pending and proprietary pluripotent stem cell differentiation technology platform TFome™ was developed in...

  • Associate Scientist/Scientist, In vivo pharmacology

    4 weeks ago

    cambridge, United States Third Rock Ventures Full time

    Associate Scientist/Scientist, In vivo pharmacologyA well-funded and highly innovative start up from Third Rock Ventures is emerging out of stealth with a syndicate of marquee investors and is seeking a talented Associate Scientist/Scientist to join the Biology-In vivo pharmacology team. The Associate Scientist/Scientist will serve as the in vivo...

  • Associate Scientist/Scientist, In vivo pharmacology

    1 month ago

    Cambridge, United States Third Rock Ventures Full time

    Associate Scientist/Scientist, In vivo pharmacologyA well-funded and highly innovative start up from Third Rock Ventures is emerging out of stealth with a syndicate of marquee investors and is seeking a talented Associate Scientist/Scientist to join the Biology-In vivo pharmacology team. The Associate Scientist/Scientist will serve as the in vivo...

  • Senior Data Scientist

    3 weeks ago

    Cambridge, Massachusetts, United States BioSpace, Inc. Full time

    Job Title: Senior Data Scientist - Data Insights ExpertJob Summary:We are seeking a highly skilled Senior Data Scientist to join our team in Cambridge, MA. As a Senior Data Scientist, you will be responsible for leading advanced analytics projects, developing and implementing machine learning models, and providing data-driven insights to inform business...

  • Senior Research Scientist

    4 weeks ago

    Cambridge, Massachusetts, United States Incendia Therapeutics Inc Full time

    Job Title: Senior Research ScientistJob Summary:Incendia Therapeutics Inc is seeking a highly motivated Senior Research Scientist to join the Biotherapeutics Drug Discovery group. The successful applicant will support therapeutic antibody discovery and optimization campaigns, including leading reagent generation strategies, developing antibody campaign...

  • Senior Clinical Scientist

    6 days ago

    Cambridge, United States Eliassen Group Full time

    Sr Clinical Scientist, Bleeding Disorders, On Market Products -Cambridge MACONTEXT (client background / the program)Our Fortune500 Pharma client is seeking a strong Sr Clinical Scientist to join a collaborative team in support of high profile on market bleeding disorder pharmaceuticals. This consultant will provide valuable support to regulatory filings...

  • Senior Clinical Scientist

    7 days ago

    Cambridge, United States Eliassen Group Full time

    Sr Clinical Scientist, Bleeding Disorders, On Market Products -Cambridge MACONTEXT (client background / the program)Our Fortune500 Pharma client is seeking a strong Sr Clinical Scientist to join a collaborative team in support of high profile on market bleeding disorder pharmaceuticals. This consultant will provide valuable support to regulatory filings...

  • Senior Clinical Scientist

    6 days ago

    cambridge, United States Eliassen Group Full time

    Sr Clinical Scientist, Bleeding Disorders, On Market Products -Cambridge MACONTEXT (client background / the program)Our Fortune500 Pharma client is seeking a strong Sr Clinical Scientist to join a collaborative team in support of high profile on market bleeding disorder pharmaceuticals. This consultant will provide valuable support to regulatory filings...

  • Senior Clinical Scientist

    6 days ago

    cambridge, United States Eliassen Group Full time

    Sr Clinical Scientist, Bleeding Disorders, On Market Products -Cambridge MACONTEXT (client background / the program)Our Fortune500 Pharma client is seeking a strong Sr Clinical Scientist to join a collaborative team in support of high profile on market bleeding disorder pharmaceuticals. This consultant will provide valuable support to regulatory filings...

  • Senior/Principal Scientist, Biology

    4 weeks ago

    Cambridge, United States Crossbow Therapeutics, Inc Full time

    Crossbow Therapeutics is looking for a Senior Scientist/Principal Scientist, Biology Crossbow Therapeutics, Inc., is a biotechnology company determined to improve the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. The company’s T-Bolt™ therapies are next-generation, easily assembled...