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Scientist, Conjugation Process Development

4 months ago

Washington, Washington, D.C., United States Pfizer Full time

Why Patients Need You
Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.
What You Will Achieve
As a Scientist, you will be at the center of our operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be a member of our growing Conjugation Process Development team and will be involved in antibody-drug conjugate (ADC) process development projects ranging from early-phase clinical molecules through late-stage or commercial products. You will contribute to the development of ADC products targeting cancer to make a meaningful difference in people's lives.
With your deep knowledge in the discipline, you will be an active team member who influences at the project team level. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience and consulting others. Your ability to plan will help in preparing short-term work activities on projects. Your creativity in developing novel processes and new ideas will be used frequently. You will undertake mentoring activities to guide your team members.
It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.
How You Will Achieve It

  • With guidance from senior group members, design, execute, and interpret studies intended to answer a defined question within the defined timeframe. Design subsequent experiments upon interpretation of data.
  • Work with cytotoxic chemicals to prepare ADCs for toxicology studies, team supply and investigational purposes
  • Support transfer of processes to manufacturing sites
  • Represent Conjugation on cross-functional teams
  • Independently author technical reports and draft relevant sections of regulatory filings with aid of templates
  • Prepare and present experimental results to project teams.

Qualifications
Must-Have

  • Bachelor's Degree and 6+ years of experience or Master's degree and 4+ years of experience
  • Degree in chemistry, biochemistry, chemical engineering, or related field
  • Direct experience with antibodies, proteins, and/or bioconjugation
  • Good understanding of analytical protein characterization (HPLC, IEF, CE-SDS)
  • Willingness to work with highly potent cytotoxic molecules while adhering to defined safety procedures
  • Excellent oral and written communication skills

Nice-to-Have

  • Experience with tangential flow filtration
  • Statistical software use, such as JMP
  • Experience with GMP manufacturing
  • Familiarity with CMC team function
  • Experience with technology transfer to manufacturing

Work Location Assignment: On Premise
The annual base salary for this position ranges from $74,900.00 to $124, In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | ). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development