Principal Scientist, Discovery Chemistry

5 days ago


Cambridge, Massachusetts, United States Sarepta Therapeutics Full time
About the Role

We are seeking a highly skilled and experienced Principal Scientist to join our RNA Research group at Sarepta Therapeutics. As a key member of our dynamic and fast-paced chemistry team, you will be responsible for designing and conducting novel oligonucleotide conjugates synthesis, purification, and characterization. You will also apply state-of-the-art delivery methods to achieve in vivo proof of concept and develop efficient and scalable synthetic methods and routes.

Key Responsibilities
  • Design and conduct novel oligonucleotide conjugates synthesis, purification, and characterization
  • Apply state-of-the-art delivery methods to achieve in vivo proof of concept
  • Develop efficient and scalable synthetic methods and routes
  • Develop and utilize innovative synthetic, medicinal chemistry and/or chemical biology problem solving skills coupled with analysis of diverse data sets to build structure-activity relationships
  • Act as key member of a multidisciplinary RNA research team, assisting with development of project strategy, and analysis and communication of complex data
  • Serves as an in-house oligonucleotide and delivery chemistry expert
  • Drive the writing of technical reports to support patent applications and manuscript preparations
  • Coordinate and manage collaborations and CRO operations to ensure deliverables meet project needs
  • Organize workstreams and complete individual and team objectives to maintain project timelines
  • Supervise and mentor junior staff
Requirements
  • PhD with 8+ years in organic chemistry, biochemistry, or related fields industry experience; or M.S. with 12+ years of experience
  • Strong experience in organic chemistry and multi-step organic synthesis is a must; Hands-on experience with manual and automated systems for solid-phase synthesis of peptides and nucleic acids is essential for this role
  • Previous experience in the design, chemical optimization, and formulation/delivery of peptides and/or oligonucleotide therapeutics is highly desirable
  • Experience with using analytical techniques/instrumentation for peptides and/or oligonucleotides purification and characterization such as Reverse Phase (HPLC/UPLC), MALDI-TOF and Liquid Chromatography Mass Spectrometry (LC-MS) is a plus
  • Track record with the ability to execute multiple concurrent research projects within a cross-functional team environment
  • Solid written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, and attention to detail are necessary
What We Offer

We offer a competitive compensation and benefit package, including a targeted salary range of $140,000 - $175,000 per year. Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.


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