Senior Scientist X-Ray Crystallography
2 weeks ago
Job Title: Senior Scientist Structural Biologist | X-Ray Crystallography
Location: Greater Boston
About the Company: Pledge Therapeutics is an innovative start-up dedicated to advancing treatments in immunology and virology. We are passionate about developing novel therapies addressing unmet medical needs in immune-oncology and viral infections. Leveraging our state-of-the-art discovery platform, we have developed high-quality medicinal leads for multiple exciting drug targets that can potentially revise existing treatment paradigms. Our breakthrough discoveries are ready to be transitioned from the lab to the clinic.
About the Role: We seek an enthusiastic scientist capable of solving the challenges associated with leading-edge discoveries. The successful candidate will integrate into an international and multidisciplinary team of scientists, engage in different research areas and work cross-functionally with the IO and Virology team to leverage crystallography to solve key molecular structures, produce high-quality proteins and contribute to the development and advancement of novel therapeutic strategies. This scientist is the vanguard of our R&D efforts, capable of adapting to any situation and responding swiftly to changing conditions. From urgent research studies to critical experiments, this team member executes efficiently and effectively.
Responsibilities:
- Leverage crystallography experience to solve crystal structures of key targets/molecules including protein crystallography, initial screening, crystal quality optimization, data collection, and structure determination
- Work cross-functionally with IO / Virology teams to produce proteins, including designing the methodology and performing the purification of proteins of therapeutic interest to provide high-quality material for the advancement of drug discovery campaigns
- Collaborates with biologists, biophysicists, biochemists, structural biologists, and medicinal chemists to develop comprehensive approaches to ensure target viability and address specific project needs
- Establish protocols to characterize target proteins for small molecule
Qualifications:
- Master / PhD degree in Structural Biology / Protein Biochemistry
- 3-5 years of work experience as a bench scientist in industry (e.g., biotech, pharma)
- Experience Protein Purification for different expression systems using multiple techniques
- Preference will be given to candidates who have direct experience in enzymology and crystallization techniques (co-crystallization, seeding, cross-seeding, soaking, harvesting, and freezing)
- Familiar with chemistry and protein computational techniques
- Champion a “can do" attitude and flexibility to adjust as R&D priorities shift
Job Type: Full-time, Work Permit, Equal Opportunity Employment
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