Principal Scientist, Protein
2 months ago
Principal Scientist, Protein & Antibody Engineering
About Pledge Therapeutics:
Pledge Therapeutics is an innovative start-up dedicated to advancing treatments in immunology, oncology, and virology. We are passionate about developing novel therapies that improve the lives of patients. Leveraging our state-of-the-art discovery platform, we have developed high-quality, preclinical drug candidates for multiple exciting drug targets with the potential to transform existing treatment paradigms.
Job Description:
We seek an enthusiastic and skilled senior scientist or principal scientist to spearhead protein and antibody engineering efforts within our Rapid Response Group (RRG), a specialized team in our Discovery Division. The RRG operates with a hands-on, mission-focused approach, parachuting into high-impact projects to develop critical tools, methodologies, and data that enhance our therapeutic programs. The successful candidate will be a key member of this elite team, driving research on protein targets and therapeutic development. In this role you will balance high-level scientific ideation with hands-on execution at the bench.
Key Responsibilities:
- Lead the design, optimization, and development of a range of antibody formats (Fab, scFv, VHH, etc.), fusion proteins, and multi-specific antibodies.
- Drive multi-targeting strategies in biologics design, focusing on bispecific, tri-specific, or dual-receptor targeting approaches.
- Design and implement affinity maturation libraries using display platforms (e.g., phage, yeast) to improve affinity, potency, and stability.
- Leverage structural data, computational insights, and other experimental results to optimize and advance antibody variants.
- Develop innovative cloning strategies, construct design, and purification protocols for high-quality protein production.
- Oversee protein expression in insect and mammalian systems, troubleshooting for yield, stability, and characterization using advanced techniques (e.g., chromatography, mass spectrometry).
- Create and implement functional and binding assays to guide lead candidate selection as well as mechanism of action studies.
- Stay current on scientific advancements, technologies, and methodologies to enhance discovery and optimization efforts.
- Synthesize data and communicate progress in regular meetings, ensuring alignment with project timelines.
- Foster scientific rigor, high productivity, and efficiency, with a results-oriented mindset of accountability and team success.
- Provide thoughtful leadership and lead from the front encouraging innovation and collaboration.
Qualifications:
- PhD in a relevant scientific discipline (Biochemistry, Molecular Biology, Biophysics, Structural Biology, Protein Chemistry, or related fields).
- 5-8 years of experience in a research-driven environment, preferably with 3-5 years of experience in the biopharma or biotech industry.
- Strong track record of scientific achievement, demonstrated by relevant publications.
- In-depth understanding of the biologics drug development process from discovery to pre-IND stages
- Extensive experience in protein design, expression systems, purification, and biophysical characterization techniques.
- Proficiency with structure- and sequence-based optimization tools, and in silico computational approaches for antibody discovery and optimization.Demonstrated ability to develop and optimize functional assays, as well as assess protein developability.
- Expertise with data analysis tools to visualize, evaluate, and communicate complex datasets effectively.
- Strong analytical, troubleshooting, and organizational skills, with meticulous attention to detail.
- Excellent work ethic and adaptability, with the ability to multitask and maintain a "can-do" attitude as R&D priorities shift.
Job Type: Full-time, Work Permit, Equal Opportunity Employment.
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