Scientist Protein Biochemist, Crystallography Expert
1 week ago
Company: Pledge Therapeutics
Location: Canton, MA
About Pledge Therapeutics:
We are a pioneering start-up dedicated to advancing treatments in immunology and virology. Our mission is to develop novel therapies addressing unmet medical needs in immune-oncology and viral infections. Leveraging our cutting-edge discovery platform, we have developed high-quality medicinal leads for multiple exciting drug targets that can potentially revolutionize existing treatment paradigms.
Job Description:
Key Responsibilities:- Utilize crystallography expertise to solve crystal structures of key targets/molecules, including protein crystallography, initial screening, crystal quality optimization, data collection, and structure determination.
- Collaborate with IO / Virology teams to produce proteins, including designing the methodology and performing the purification of proteins of therapeutic interest to provide high-quality material for the advancement of drug discovery campaigns.
- Work closely with biologists, biophysicists, biochemists, structural biologists, and medicinal chemists to develop comprehensive approaches to ensure target viability and address specific project needs.
- Establish protocols to characterize target proteins for small molecule interactions.
- Master / PhD degree in Structural Biology / Protein Biochemistry.
- 3-5 years of work experience as a bench scientist in industry (e.g., biotech, pharma).
- Experience in protein purification for different expression systems using multiple techniques.
- Preference will be given to candidates who have direct experience in enzymology and crystallization techniques (co-crystallization, seeding, cross-seeding, soaking, harvesting, and freezing).
- Familiarity with chemistry and protein computational techniques.
- Ability to champion a "can do" attitude and flexibility to adjust as R&D priorities shift.
Job Type: Full-time, Work Permit, Equal Opportunity Employment
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