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Senior Research Scientist X-Ray Crystallography
2 months ago
We are seeking a highly skilled and experienced Senior Scientist to join our team at Pledge Therapeutics. As a Senior Scientist, you will play a key role in advancing our research and development efforts in immunology and virology.
Key Responsibilities:
- Leverage your expertise in crystallography to solve crystal structures of key targets/molecules, including protein crystallography, initial screening, crystal quality optimization, data collection, and structure determination.
- Collaborate with our IO and Virology teams to produce high-quality proteins, including designing the methodology and performing the purification of proteins of therapeutic interest.
- Work closely with biologists, biophysicists, biochemists, structural biologists, and medicinal chemists to develop comprehensive approaches to ensure target viability and address specific project needs.
- Establish protocols to characterize target proteins for small molecule interactions.
Requirements:
- Master's or PhD degree in Structural Biology or Protein Biochemistry.
- 3-5 years of work experience as a bench scientist in industry (e.g., biotech, pharma).
- Experience in protein purification for different expression systems using multiple techniques.
- Preference will be given to candidates with direct experience in enzymology and crystallization techniques (co-crystallization, seeding, cross-seeding, soaking, harvesting, and freezing).
- Familiarity with chemistry and protein computational techniques.
- A champion of a 'can do' attitude and flexibility to adjust as R&D priorities shift.
What We Offer:
- A dynamic and international team of scientists.
- The opportunity to work on cutting-edge research and development projects.
- A comprehensive benefits package.
