Principal Scientist, Translational Discovery
4 months ago
Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
When you join BMS, you are joining a diverse, high-achieving team united by a common mission.
The Neuroscience TRC is committed to the development of transformational therapeutics for patients with neurodegenerative, neuromuscular and neurophysiological diseases. A network of external partnerships across neurodegenerative and neuropsychiatric diseases and treatment modalities (small molecules, biologics and genetic medicines) supports our ambition to become leaders in neuroscience. Internal research focuses on causal human biology linking the immune system and protein misfolding to neurodegenerative disease, with an emphasis on the application of human -derived cells to study disease mechanisms.
Areas of interest include, but are not limited to, the identification of disease modifying therapies for neurodegenerative, neuro-inflammatory and neuromuscular diseases; approaches to modulate protein clearance and reduce or eliminate toxic protein production; emerging technologies (RNA, DNA targeting) that when matched to underlying causal human biology may deliver a precision medicine portfolio with a high probability of translational success; AI/ML in target identification and neurology drug discovery; neuroimaging and fluid biomarkers to track disease progression and target engagement; novel blood brain-barrier delivery technologies.
Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.
Position Summary:
The Neuroscience Thematic Research Center (Neuro TRC) leverages external collaborations and internal research to establish a diverse portfolio targeting unmet needs in neurodegenerative, neurinflammatory and neuromuscular diseases. The Senior / Principal Scientist, Translational Discovery, in collaboration with other members of the Neuro TRC, undertakes design and delivery of translational data packages that enable rapid progression of drug candidates towards clinical proof-of-concept. This position is based in Cambridge, MA, and is primarily a laboratory-based role.
Work closely with the Director and leadership team to develop the biomarker and assay strategy at the project and program team level. Drive biomarker selection for programs. Actively participate in data analyses, interpretation. Communicate results internally and externally, as aligned with TRC commitments. Review study design, contracting, quality oversight, and execution of selected studies conducted externally through CROs or research partners. Work closely and in collaboration with in-house science teams to develop and implement study designs, data analyses and interpretation that support high priority neuro projects/programs. Track budget and spend against deliverables for biomarker studies, communicating regular updates within the TRC. Draft and review internal project reports as needed; presenting scientific data at internal and external conferences.Basic Qualifications:
Bachelor’s Degree8+ years of academic and / or industry experienceOr
Master’s Degree6+ years of academic and / or industry experienceOr
Ph.D. or equivalent advanced degree in the Life Sciences 4+ years of academic and / or industry experiencePreferred Qualifications:
PhD in cellular and Molecular fields; preferably in Neuroscience stream: 2+ years in academics and 2+ additional years of Industry experience working in early R&D or Translational science. Hands on experience in immunoassay and molecular assays (ELISA, Meso-scale discovery, SIMOA, qPCR, dd-PCR, RNAseq, etc.). Specialized in identifying novel fluid biomarkers using cutting edge technologies involving transcriptomics and proteomics. Experience in managing external project at CROs or academic collaborations to obtain key data for the program Proven track record in designing, troubleshooting, analyzing and interpreting data from translational and experimental medicine type studies Experience in managing study budget tracking and tracking of individual program/project elements Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
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