Principal Scientist

2 months ago

Cambridge, United States Delphia Therapeutics Full time

Principal Scientist / Associate Director, In vivo Pharmacology


About Us:

Delphia is a biotechnology company on a mission in the service of patients to pioneer an entirely new field of cancer biology, Activation Lethality, that targets cancer’s vulnerability to oncogene overactivation. Together, we are working to advance first-in-class targeted cancer medicines that can provide better and more durable outcomes for patients, particularly where drug resistance is observed. Partnering together in a supportive, open, and collaborative environment, we share a sense of purpose, urgency and commitment to patients to approach cancer biology through a different perspective and to establish Activation Lethality as the next wave of oncology therapeutics.


The Difference You’ll Make

  • Delphia is searching for a Principal Scientist / Associate Director, In vivo Pharmacology to join the team The In vivo pharmacologist will be responsible for the development and execution of the in vivo strategy to advance a growing pipeline of first-in-class targeted cancer medicines designed to provide better outcomes for patients. The candidate will collaborate closely with the chemistry, biology, toxicology, DMPK, translational and future clinical development teams in leading our efforts designed to address key questions related to how our molecules behave in vivo.


What You’ll Do:

  • Provide in vivo pharmacology expertise to lead the design and implementation of the in vivo pharmacology strategy across Delphia’s discovery portfolio.
  • Serve as the in vivo pharmacology lead on project teams providing clear strategic direction as well as organize, maintain, and present research data at the project team level.
  • Work collaboratively with the biology, chemistry, and DMPK groups to develop an in vivo study plan for establishing PK/PD/efficacy for early molecule development as well as exploratory studies designed to understand how to leverage the novel activation lethality mechanism of action.
  • Plan, analyze and interpret in vivo efficacy studies in collaboration with a contract research organization in order to support program goals and objectives.
  • Prepare regulatory submission documentation, author in vivo pharmacology sections of regulatory documents.
  • Identify and manage consultants and vendors for additional in vivo pharmacology support as necessary.


What you bring:

  • PhD in a biology with 5+ years of experience in biotech/pharmaceutical industry.
  • Expertise and a broad understanding the design, execution and analysis of in vivo studies with small molecule oncology drugs.
  • Extensive knowledge of basic biology, PK, toxicology, and clinical study design.
  • Demonstrate innovative thinking driving towards cutting-edge approaches.
  • Proactive at solving complex problems within a collaborative, fast-paced, matrixed team environment.
  • Experience and proficiency in managing activities at CROs and preparing data packages for regulatory submission.
  • Experience leading in vivo pharmacology efforts for early-stage discovery projects and familiarity with the drug discovery and development process.
  • Ability to operate objectively and independently as a leader and as a member of a team.
  • Excellent verbal and written communication skills necessary for effective collaboration and presentation of data.
  • Comfort operating in complexity and ambiguity in a fast-paced environment interacting with consultants, external vendors, and internal cross-functional teams.

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