Senior Scientist, Protein Conjugation Expert

4 weeks ago

Cambridge, Massachusetts, United States Fable Therapeutics Full time

About Fable Therapeutics:

We are a discovery-stage biotechnology company that develops purpose-built biologics designed to overcome therapeutic index limitations and channel therapeutic response where and when it matters.

Our company is powered by state-of-the-art structure and sequence-based protein language models. Founded by leading ML scientists and veteran biotech entrepreneurs together with top-tier venture capital firms, we have recently initiated our internal therapeutic pipeline and have enacted a growing list of pharma research collaborations.

Backed by a $40M Series A investment co-led by Versant Ventures and DCVC, we are positioned to lead in the purposeful integration of biology and computation to solve complex medical challenges. Our aspiration is to write the next chapter of what protein-based therapeutics can do.

Job Summary:

We are seeking a highly talented and motivated scientist to join our growing team and establish our in-house protein conjugation capabilities. As an expert in biologics drug discovery, you will be primarily responsible for conjugation of antibodies and other protein-based candidate therapeutics from our bespoke AI designed libraries using a variety of chemistries and payloads.

You will have the opportunity to contribute to designing the ideal lab environment to support your protein conjugation workflows, including analytics and robotics/automation. The data you generate will be used to explore new concepts and to design potent therapeutic candidates.

Key Responsibilities:

  • Design and evaluation of different linker/payload structures and methods of protein conjugation
  • Generation of antibody and other protein conjugates using a variety of chemistries and payloads, with opportunity to design and build the lab
  • Characterization of the protein conjugates in robust bioanalytical and in vitro assays
  • Use of liquid handlers and automation for high-throughput methods
  • Binding assays based on SPR, BLI and ELISA
  • Careful documentation and record-keeping of scientific results
  • Upload of data to databases and LIMS systems
  • Curation of data for ingestion and utilization by ML scientists
  • Mentoring and training of junior scientists

Requirements:

  • PhD/postdoc in Protein Engineering, Bioengineering, Protein Chemistry or similar field and 4+ years industry experience in biologics discovery and protein science OR MSc and 6+ years experience
  • Proven track record in Antibody Drug Conjugates (ADCs) and other protein conjugation technologies
  • Experience using various analytical instruments and methods (aSEC, aHIC, DSC, DSF, Mass Spectrometry, etc.) for the biophysical characterization of protein conjugates
  • Familiarity with liquid-handling and high-throughput systems
  • Committed to digital workflows and the lab of the future
  • Ability to work efficiently in a close-knit team and deliver high quality, reproducible data in a fast-paced environment
  • Attentive to detail and a careful experimenter
  • Ability to take initiative and improve processes
  • An excellent communicator and presenter of scientific data
  • Passionate about the power of AI to transform biotherapeutics
  • Focused on quantifiable results and data driven decisions
  • Collaborative and inclusive mindset

We are an equal opportunity employer and we value diversity and inclusion. We provide an open, collegial, and friendly work environment where we empower people and provide them with opportunities to develop their long-term careers. We do not discriminate on the basis of race, color, religion, sexual orientation, gender, age, physical or mental disability, or any other status protected under federal, state, or local law.

For accommodations during the interview process, please email hr@fabletx.com

  • Senior Scientist, Protein Conjugation Expert

    4 weeks ago

    Cambridge, Massachusetts, United States Fable Therapeutics Full time

    About UsFable Therapeutics is a biotechnology company that develops innovative biologics designed to overcome therapeutic index limitations. Our team is powered by state-of-the-art structure and sequence-based protein language models.We are seeking a highly skilled Senior Scientist to join our team and establish our in-house protein conjugation capabilities....

  • Principal Scientist, Protein Sciences

    4 weeks ago

    Cambridge, Massachusetts, United States Flagship Ventures Full time

    Role SummaryFlagship Ventures is seeking a dedicated and skilled Principal Scientist, Protein Sciences to join our team. The role will focus on peptide or antibody production, discovery, and engineering through hit optimization and lead identification.Key ResponsibilitiesLead and manage projects focused on peptide or antibody production, discovery, and...

  • Senior Research Scientist

    4 weeks ago

    Cambridge, Massachusetts, United States Incendia Therapeutics Inc Full time

    Job Title: Senior Research ScientistJob Summary:Incendia Therapeutics Inc is seeking a highly motivated Senior Research Scientist to join the Biotherapeutics Drug Discovery group. The successful applicant will support therapeutic antibody discovery and optimization campaigns, including leading reagent generation strategies, developing antibody campaign...

  • Senior/Principal Scientist, Biology

    4 weeks ago

    Cambridge, Massachusetts, United States Crossbow Therapeutics, Inc Full time

    Crossbow Therapeutics, Inc. is a biotechnology company dedicated to improving the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. Our T-BoltTM therapies are next-generation, easily assembled immunotherapies directed with high precision at previously unreachable cancer cell targets. Our approach...

  • Senior Research Scientist

    4 weeks ago

    Cambridge, Massachusetts, United States Synectics Inc Full time

    Job SummaryWe are seeking a highly skilled and motivated scientist to join our Immunology Discovery department in Cambridge, MA. The successful candidate will be responsible for developing therapeutic molecules using recombinant DNA technology, expression, and purification of recombinant proteins, as well as testing purified proteins in functional cellular...

  • Senior Data Scientist

    4 weeks ago

    Cambridge, Massachusetts, United States BioSpace, Inc. Full time

    Job Title: Senior Data Scientist - Data Insights ExpertJob Summary:We are seeking a highly skilled Senior Data Scientist to join our team in Cambridge, MA. As a Senior Data Scientist, you will be responsible for leading advanced analytics projects, developing and implementing machine learning models, and providing data-driven insights to inform business...

  • Senior Research Scientist, Protein Sciences and Structural Biology

    1 month ago

    Cambridge, Massachusetts, United States Skills Alliance Full time

    Job SummaryWe are seeking a highly motivated and passionate research associate to support drug discovery projects. The successful candidate will have a solid understanding of protein biochemistry and molecular biology, with experience in structural biology being advantageous.Key Responsibilities:Develop and execute strategies to clone and express recombinant...

  • Senior Scientist, Machine Learning Antigen Design Expert

    4 weeks ago

    Cambridge, Massachusetts, United States Flagship Pioneering, Inc. Full time

    About Apriori BioApriori Bio is a pioneering biotechnology company dedicated to developing a world protected against viral threats. Our unique technology platform, Octavia, enables us to survey the entire landscape of existing and potential variants to design new vaccines against the most threatening viruses. Octavia also informs public health policy in...

  • Senior Scientist, Biology Lead

    4 weeks ago

    Cambridge, Massachusetts, United States Crossbow Therapeutics, Inc Full time

    About the OpportunityCrossbow Therapeutics, Inc. is a biotechnology company dedicated to revolutionizing cancer treatment through innovative immunotherapies. We are seeking a highly skilled Senior Scientist/Principal Scientist, Biology to join our dynamic team.Key Responsibilities:Lead programs from discovery through DC nomination, driving scientific rigor...

  • Senior Neurodegeneration Research Scientist

    3 weeks ago

    Cambridge, Massachusetts, United States QurAlis Full time

    About the CompanyAt QurAlis, we are a clinical-stage biotechnology company pioneering precision medicines for neurodegenerative diseases. Our team of internationally recognized neurodegenerative biologists from Harvard Medical School and Harvard University works with a relentless pursuit of knowledge and a precise attention to craft to discover and develop...

  • Senior Biomolecule Design Scientist

    3 days ago

    Cambridge, Massachusetts, United States Flagship Ventures Full time

    Role SummaryFlagship Ventures is seeking a highly skilled Senior Biomolecule Design Scientist to join our team. As a key member of our cross-functional team, you will be responsible for developing and deploying machine learning models for sequence design. Your expertise in MLOps, model training, and deployment will be instrumental in advancing our...

  • Senior Scientist Cell Culture Leader

    4 weeks ago

    Cambridge, Massachusetts, United States Evonik Industries Full time

    Lead the Way in Cell Culture InnovationEvonik Industries is seeking a talented and motivated individual to join our team as the Principal Scientist Cell Culture. This role is located onsite at our Cambridge, MA location.ResponsibilitiesSpearhead the establishment and growth of the Cell Culture team within the facility.Drive recruitment efforts to assemble a...

  • Senior Scientist, Cell-based Assays Specialist

    1 month ago

    Cambridge, Massachusetts, United States Fable Therapeutics Full time

    About Us:Fable Therapeutics is a pioneering biotechnology company that leverages cutting-edge protein language models to develop innovative therapeutic solutions. Founded by leading ML scientists and veteran biotech entrepreneurs, we have established a strong foundation for our internal therapeutic pipeline and have forged strategic partnerships with...

  • Senior Data Scientist

    4 weeks ago

    Cambridge, Massachusetts, United States Takeda Pharmaceutical Company Ltd Full time

    Job Description:We are seeking a highly skilled Senior Data Scientist to join our Advanced Analytics and Digital Engineering team in Takeda Vaccines. As a Senior Data Scientist, you will be responsible for leading the development and implementation of advanced data analytics solutions to drive business growth and improve patient outcomes.Key...

  • Scientist I

    4 weeks ago

    Cambridge, Massachusetts, United States Orion Group Full time

    Job Title: Scientist I - Recombinant DNA Technology SpecialistOrion Group is seeking a highly motivated and passionate scientist to join our client's research team in Immunology Discovery based in Cambridge, MA.The successful candidate will focus on making therapeutic molecules using recombinant DNA technology, expression/purification of recombinant...

  • Senior Research Scientist

    4 weeks ago

    Cambridge, Massachusetts, United States Mass General Brigham Full time

    Job SummaryWe are seeking a highly skilled Senior Research Scientist to join our team at Mass General Brigham. The successful candidate will have a strong background in medical device interoperability and cybersecurity, with a proven track record of leading research projects and managing technical staff.Key ResponsibilitiesResearch and Development: The...

  • Research Scientist

    4 weeks ago

    Cambridge, Massachusetts, United States Orion Group Full time

    Orion Group is seeking a highly motivated and passionate scientist in cellular immunology to join our client's research team in Immunology Discovery based in Cambridge MA.The candidate will focus on making therapeutic molecules using recombinant DNA technology, expression/purification of recombinant proteins, testing purified proteins in functional cellular...

  • Senior Scientist, Machine Learning Antigen Design Specialist

    4 weeks ago

    Cambridge, Massachusetts, United States Flagship Pioneering, Inc. Full time

    Job Summary: Flagship Pioneering, Inc. is seeking a highly skilled Senior Scientist to join our team of computational immunologists and vaccine designers. As a key member of our team, you will leverage your expertise in machine learning and computational biology to design novel antigens and evaluate subsequent vaccine responses.Key Responsibilities:* Design,...

  • Research Associate II/Senior Research Associate, Protein Engineering and Molecular Sciences

    4 weeks ago

    Cambridge, Massachusetts, United States Repertoire Immune Medicines Full time

    Job OverviewWe are seeking a highly skilled Research Associate II/Senior Research Associate to join our Protein Engineering and Molecular Sciences Team at Repertoire Immune Medicines. The ideal candidate will have hands-on experience in analytical and biophysical QC of protein batches, including size exclusion HPLC, SDS-PAGE, DSF, ELISA, and/or Octet/SPR....

  • Senior Director/Program Lead, Biology

    4 weeks ago

    Cambridge, Massachusetts, United States Fog pharma Full time

    Transformative Opportunity in Oncology Drug DevelopmentAt FogPharma, we're pioneering the discovery and development of Helicon therapeutics, peptides capable of efficient cell entry and modulation of both protein-protein and protein-DNA interactions. As a Senior Director/Program Lead, Biology, you'll drive cell and translational biology for multiple oncology...