Research Associate II/Senior Research Associate, Protein Engineering and Molecular Sciences

4 weeks ago


Cambridge, Massachusetts, United States Repertoire Immune Medicines Full time
Job Overview

We are seeking a highly skilled Research Associate II/Senior Research Associate to join our Protein Engineering and Molecular Sciences Team at Repertoire Immune Medicines. The ideal candidate will have hands-on experience in analytical and biophysical QC of protein batches, including size exclusion HPLC, SDS-PAGE, DSF, ELISA, and/or Octet/SPR. The selected candidate will work at the bench to QC TCR bispecifics and MHC proteins, conduct stability/developability assessments to prioritize therapeutic leads, and develop robust assays for tech transfer to manufacturing partners.

Key Responsibilities
  • Perform analytical and biophysical QC of protein batches using techniques such as size exclusion HPLC, SDS-PAGE, DSF, ELISA, and/or Octet/SPR.
  • Develop and document robust analytical assays for tech transfer to manufacturing partners.
  • Conduct comparability, developability, and accelerated stability assessments of lead therapeutic molecules.
  • Capture primary data, establish and maintain SOPs, and document work as required in Electronic Laboratory Notebook (ELN), maintaining up to date records.
  • Present data routinely to the Protein Sciences group and other multidisciplinary groups.
Qualifications/Experience
  • BS/MS in Biochemistry, Biology, Bioengineering, Immunology, or a similar field.
  • 2+ years of academic or biotech/pharma laboratory experience.
  • Experience with HPLC systems and with biochemical assays such as ELISA, SDS-PAGE, and DSF.
  • Experience with Octet, SPR, or flow cytometry a plus.
  • Strong organizational and communication skills along with excellent attention to details.
  • Enjoys working in a collaborative, fast-paced, and quickly changing environment.

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