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DMPK Principal Scientist

2 months ago

San Diego, California, United States Genesis Therapeutics Full time
About the Role

We are seeking a highly skilled and experienced DMPK Principal Scientist to join our team at Genesis Therapeutics. As a key member of our research team, you will be responsible for driving the overall PKPD modeling and simulation effort to support projects from early research through early clinical development.

Key Responsibilities
  • Represent DMPK as the technical expert on project teams, providing scientific and strategic leadership for all stages of discovery and early development.
  • Design, develop, execute (or manage conduct) and interpret high-throughput and mechanistic ADME assays and data to enable small molecule drug discovery efforts.
  • Design, interpret and integrate pharmacokinetic (PK), pharmacokinetic/pharmacodynamic (PK/PD), and ADME data to enable estimation of human pharmacokinetics and human pharmacologically active dose.
  • Partner with AI engineer on ADME predictive model.
  • Preparation of nonclinical DMPK/ADME reports and documents for candidate nomination and regulatory filing.
  • Collaborate and communicate across departments to guide understanding of ADME studies and fundamentals to support drug discovery.
Requirements
  • A Master's or Ph.D. in Pharmaceutics, Pharmacokinetics, Pharmacology, Biomedical engineering or related discipline with 8+ years Industrial experience in Drug Discovery & Development.
  • Expertise in the development on conduct of in vitro and in vivo ADME assays.
  • Experience in LC/MS/MS bioanalytical method development and application.
  • Knowledge in the conduct, analysis, and interpretation of in vivo pharmacokinetics and PKPD studies.
  • Ability to conduct self-directed research and to work effectively in a dynamic environment with a diverse team of coworkers.
  • Solid written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, and attention to detail are necessary.
  • Level determined will be commensurate with experience.
What We Offer
  • Competitive Pay
  • Stock Option Eligibility
  • 401(k) Plan
  • Open PTO Policy
  • Paid Company Holidays
  • Free lunch and snacks at our offices
  • Health Care Plan, including Medical, Dental, and Vision, fully covered for the employees.