Principal Scientist, DMPK

17 hours ago


South San Francisco, California, United States Cytokinetics Full time
Job Summary

Cytokinetics is a leading biopharmaceutical company focused on developing innovative treatments for cardiovascular diseases. We are seeking a highly skilled Principal Scientist, DMPK to join our team and contribute to the discovery and development of novel muscle activators and inhibitors.

Key Responsibilities
  • Design and conduct experiments to understand the absorption, distribution, metabolism, and excretion (ADME) properties of drug candidates.
  • Collaborate with medicinal chemists to design and evaluate drug candidates based on their ADME profiles and drug-drug interaction liabilities.
  • Lead and manage in-vivo and in-vitro ADME/PK studies to support drug discovery and early development.
  • Provide technical expertise and support in the use of standard PK and PD data analysis software.
  • Evaluate and interpret in vitro and in vivo DMPK data to inform project decisions.
  • Develop and optimize analytical methods for quantitating compounds and metabolites in biological fluids.
Requirements
  • PhD degree in Pharmacokinetics, Drug Metabolism, or a related life sciences degree with 12+ years of experience in small molecule development.
  • Demonstrated experience designing and conducting experiments in support of DMPK lead optimization and candidate selection activities.
  • Hands-on experience designing, analyzing, and interpreting drug metabolism and PK studies.
  • Expertise in state-of-the-art bioanalysis by LC/MS/MS and related techniques, metabolite identification, and reactive metabolite chemistry.
What We Offer

Cytokinetics is an equal opportunity employer committed to diversity and inclusion. We offer a competitive salary range of $198,000-$242,000 USD and a comprehensive benefits package. If you are passionate about advancing cardiovascular medicine and have the skills and expertise to succeed in this role, we encourage you to apply.



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