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Senior Research Scientist

2 months ago

San Diego, California, United States Abbott Full time

About the Opportunity

This position is located in the Infectious Diseases Division at Abbott, a leading global healthcare company. We are seeking an experienced Senior Research Scientist to oversee and conduct cutting-edge research in enzymology, to identify, characterize, optimize and develop proteins used for nucleic acid amplification and sample preparation technologies.

Key Responsibilities

  • Lead protein characterization, optimization and development efforts, from design of experiments through laboratory studies
  • Perform kinetic, thermodynamic and structure-function studies
  • Apply computational modeling to drive protein characterization and optimization efforts
  • Initiate and oversee proteomics efforts in-house and via collaboration
  • Provide cloning, protein expression, separation and purification expertise
  • Implement mutagenesis studies to help characterize and optimize proteins of interest
  • Drive the introduction of new, optimized and/or modified proteins to improve product performance
  • Design and implement procedures, processes and key performance indicators to monitor, characterize and QC proteins
  • Provide high-level analysis of experimental results
  • Provide written reports and oral presentations to executives
  • Ability to work as part of a team with excellent communication skills

Required Qualifications

  • Bachelor's Degree in Biochemistry/Biophysics/Protein chemistry, or a closely related field and 10 years of experience in a similar area

Preferred Qualifications

  • Biochemistry/Biophysics/Protein chemistry, or a closely related field and 10 years of experience
  • Minimum ten years of full-time laboratory experience in an industrial setting
  • Hands-on expertise using kinetic, thermodynamic and structure-function experimental approaches
  • Expertise with computational modeling of proteins and protein/nucleic acid interactions to drive characterization of protein functionality and to drive the incorporations of protein modifications to improve/alter function
  • Extensive experience characterizing DNA/RNA interacting/binding proteins
  • Expertise in optimizing protein expression and purification methods
  • Expertise in developing, optimizing and performing in vitro enzymatic assays
  • Experience with high-throughput genetic/molecular screening a plus
  • Inventive, with ability to implement ideas in the laboratory
  • Strong problem-solving skills and the ability to analyze complex enzymatic processes
  • Extensive hands-on experience driving the analytical, biological and functional characterization of proteins
  • Expertise in computational structure/function modeling of DNA/RNA binding proteins
  • Track record of modifying and optimizing protein function to improve key performance characteristics
  • Ability to work as part of a team with excellent communication skills