Associate Director, Pharmacometrician

1 month ago


Redwood City, California, United States Revolution Medicines Full time
Revolution Medicines

We are a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.

The Opportunity

We are seeking a passionate and energetic individual with strong PKPD modeling background to be part of the Nonclinical Development and Clinical Pharmacology (NDCP) Organization.

Key Responsibilities
  • Establish population PK models to identify intrinsic and extrinsic factors that impact PK, and to guide dose/schedule optimization and recommended phase 2 dose/schedule (RP2Ds) selection.
  • Perform model-based simulations to optimize dosing to inform trial designs and clinical outcomes.
  • Ensure quality and integrity of modeling and simulation results.
  • Author and provide technical input for regulatory documents and submissions related to all aspects of pharmacometrics.
  • Engage and work with consultants and/or CROs on pharmacometrics activities to complement in-house knowledge/expertise and capacities.
Requirements
  • A Ph.D. or Pharm.D. with 5+ years of experience in PKPD Modeling & Simulation.
  • Extensive hands-on experience using NONMEM modeling software is a must.
  • Familiar with common PKPD/TGI models and able to write customized NONMEM models.
  • At least two years of relevant work experience in pharmaceutical companies.
  • Proficiency in R programming is desired.
  • Able to take dynamically assigned pharmacometrics tasks and deliver the results in a timely manner.
  • Excellent verbal and written communication skills, and ability to clearly convey complex concepts and findings to both non-specialist and specialist audiences.
Preferred Skills
  • Have prior knowledge or familiarity with longitudinal model analysis (e.g. ctDNA and tumor shrinkage).
  • Have prior knowledge or familiarity with ER analysis for oncology compounds.
  • Familiar with data handling.

The base salary range for this full-time position is $175,000 to $210,000 for candidates based at our headquarters in Redwood City, CA. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

We take protection and security of personal data very seriously and respect your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.



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