Principal Scientist Bioprocess Development

22 hours ago

Emeryville, California, United States UPSIDE Foods Full time
About UPSIDE Foods

UPSIDE Foods is a pioneering company in the field of cultivated meat, growing meat, poultry, and seafood directly from real animal cells. Our mission is to create a more sustainable and humane food system, while still providing people with the meat they love.

Job Description

We are seeking a highly experienced Principal Scientist, Bioprocess Development to join our team. This role will play a critical part in the scale-up of our novel bioprocesses for cultivated meat production. The successful candidate will have a strong background in mammalian cell culture bioprocess development and process transfer across scales, with experience in cGMP operations and/or pilot plant operations.

Key Responsibilities
  • Lead technology transfer activities and technical support of processes in production, including managing person-in-plant support as part of the Manufacturing Sciences and Technology (MSAT) sub-team with BPD.
  • Independently design, oversee, and analyze experiments ranging from bench through pilot scale, leading to process transfer to commercial scale and manufacturing support.
  • Drive the evaluation, development, and implementation of new manufacturing technologies.
  • Lead new process scale-up, including selection, installation, and evaluation of new bioreactor technologies and development of operating procedures.
  • Act as the subject matter technical expert for large-scale animal cell bioprocesses.
  • Mentor and lead junior team members to accomplish project goals.
  • Support regulatory filings and facility startup as needed.
Requirements
  • A total of 15+ years of experience in mammalian cell culture bioprocess development and process transfer across scales in academic and industry settings.
  • Advanced degrees are preferred with a combined equivalent of relevant industrial experience in cell biology, molecular biology, bioengineering, chemical engineering, or related life sciences field.
  • Experienced with cGMP operations and/or pilot plant operations with 5+ years management experience leading staff and teams responsible for process development and/or technology transfer and manufacturing support.
  • Experience with leading the development and/or tech transfer of upstream bioreactor modes of operations such as fed-batch or perfusion into production with animal or mammalian suspension cells at large scale is required.
  • Expertise in development of new bioprocesses, and process transfer to production, including scale-up and scale-down of bioreactors and bioprocess controller systems.
  • Ability to relate with people at all levels within an organization, including diverse cultures.
  • Comfortable working and mentoring in a team-based environment.
  • Must be willing and able to work evenings and weekends when needed.
  • Experience in data analysis platforms (e.g. JMP, Minitab), including statistical analysis and presenting data in table and graph forms.
What You'll Work With
  • The BPD team, and especially the MSAT subteam, interfaces with all aspects of R&D, BPD, and Manufacturing, and this person will accordingly work with stakeholders across the organization to design studies and manage handoffs of materials and data.
  • To support tech transfer and manufacturing operations, this person will manage teams responsible for preparing process documentation, transferring processes into manufacturing, and providing on-floor support.
Key Contributions in First Year
  • Work within the MSAT subteam of BPD to enable tech transfer and support of large-scale bioprocess operations.
  • Lead efficient technology transfer workflows.
  • Lead dedicated manufacturing support.
  • Enable testing of most current processes at bench and pilot scales prior to technology transfer to commercial scales.
  • Implement a dedicated pilot-scale suspension production function to support Food R&D prototyping efforts.
Compensation and Benefits

We offer a competitive compensation package, including stock options, 90-100% employer-paid healthcare premiums, pet insurance, unlimited PTO, and company-sponsored learning and development opportunities.

UPSIDE Foods is an equal opportunity employer and values diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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