Senior Scientist, Biochemistry

1 month ago

Watertown, Massachusetts, United States Treeline Biosciences Full time
About Treeline Biosciences

Treeline Biosciences is a pioneering biotechnology company that leverages cutting-edge tools in genomics, lead discovery, medicinal chemistry, and computation to accelerate the development of innovative medicines against challenging targets in cancer and other life-threatening diseases.

About the Role

We are seeking an experienced and highly motivated Biochemist & Biophysicist to join our team in Watertown. The successful candidate will play a critical role in supporting our drug discovery programs by collaborating with our multi-disciplinary Lead Discovery organization and contributing to the development of new biophysical assays to characterize protein-small molecule and protein-protein interactions.

Key Responsibilities
  • Design and implement biophysical assays to support hit ID, hit to lead, and lead optimization activities.
  • Utilize a range of biophysical techniques, including SPR, DSF, MS, DLS, and MST, to advance drug discovery.
  • Analyze and interpret biophysical data to mechanistically deconvolute the molecular mechanism of action of small molecule hits.
  • Communicate biophysical data as a subject matter expert and biophysics representative on project teams.
  • Collaborate with chemistry, biology, lead discovery, and medicine design to characterize and establish SAR to drive the hit-to-lead process.
  • Propose and evaluate new approaches and technologies.
  • Provide biophysics leadership to project teams.
Requirements
  • PhD in Biophysics, Biochemistry, Chemistry, Chemical Biology or related discipline with 2-3 years of relevant postdoctoral training.
  • 5+ years of experience in biotech/pharma industry with a track record of hit-finding, hit-to-lead, and lead optimization to delivering small molecule development candidates.
  • Previous experience in small molecule drug discovery, specifically biophysical assay development and characterization of small molecule inhibitors and protein-ligand binding interactions.
  • Strong knowledge of biophysical methods and theory with proven hands-on expertise applying biophysics for interaction analysis.
  • Experience with integrated application of a broad array of biophysical or biochemical methods for drug discovery is a plus.
  • Attention to detail and good troubleshooting and problem-solving skills.
  • Strong written and oral communication skills, excellent interpersonal skills, with demonstrated ability to work collaboratively on multidisciplinary teams.
Preferred Qualifications
  • Ability to lead in a matrix environment, and for example, act as point of contact on behalf of Lead Discovery within the broader project team.
  • Experience with fragment-based lead discovery, covalent lead discovery, and DEL are a plus.
  • Strong hands-on biochemistry experience or expertise in enzymology.
  • Working knowledge of adjacent disciplines (biochemistry, structural biology, protein purification, biology, chemistry).
  • Experience in working with challenging proteins.
  • Experience working with CROs.

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