Senior Medicinal Chemist, Oligonucleotides
5 days ago
Verve Therapeutics, Inc. is a clinical-stage genetic medicines company dedicated to solving the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics, and gene-editing, Verve is pioneering a new approach to the care of cardiovascular disease, potentially transforming treatment from chronic management to single-course gene editing medicines.
The PositionVerve Therapeutics, Inc. is seeking a highly experienced Senior Medicinal Chemist to oversee our chemistry team focused on oligonucleotides drug design and synthesis. The successful candidate will be accountable for supporting platform strategy and building the medicinal chemistry platform for gene editing. This individual will work collaboratively with a multi-disciplinary team to support the progression of gene-editor-based therapeutic modalities from early research to clinic.
Key Responsibilities- Define project-related oligonucleotide / guide RNA medicinal chemistry strategies and overall strategies for platform innovation as well as applying those innovative strategies to drug discovery projects from target ID to hit identification, lead selection, and candidate nomination.
- Be an integral part of platform leadership team and lead all the oligonucleotide medicinal chemistry related efforts to secure key project milestones.
- Define medicinal chemistry strategy for oligonucleotides / guide RNAs and clearly articulate the plans with risk mitigation steps.
- Proven ability as a leader in coaching and providing feedback and directions to enable employee development and growth.
- Provide guidance to internal and external chemists and support all aspects of oligonucleotide operation including small, medium and large-scale synthesis.
- Strong organizational leadership skills and dynamic range with a proven track record in setting vision and strategy while managing the day-to-day tactical responsibilities.
- Excellent communication, cross-functional and collaborative leadership skills with the ability to influence key stakeholders and provide direction to direct reports and cross-functional teams members.
- B.S. in chemistry or similar area with 15+ years of experience in oligonucleotide chemistry in a drug discovery setting OR;
- M.S. in chemistry or similar area with 13+ years of experience in oligonucleotide chemistry in a drug discovery setting OR;
- Ph.D. in chemistry or similar area with 12+ years of experience in oligonucleotide chemistry in a drug discovery setting
- Experience in solid phase oligonucleotide chemistry and hands-on experience with various oligonucleotide synthesizers are a must.
- Experience in oligonucleotide purifications using different chromatographic approaches and hands-on experience with state-of-the-art chromatographic infrastructure.
- Experience in phosphoramidite chemistry and oligonucleotide conjugation strategies to attach ligands such as carbohydrates, lipids, peptides. Knowledge in nucleoside/nucleotide chemistry is desirable.
- Strong change and learning agility with a proven history of bringing new ideas and creativity, both scientifically and strategically.
- Demonstrated ability to be nimble and thrive in a fast-paced, dynamic culture and environment.
- Energetic, motivational, positive and collaborative leadership skills in bringing out the best in others and leveraging capabilities to advance the organization's mission.
- Experience leading and developing a team.
- Contributing to and leading cross-functional teams to achieve company goals.
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