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Biochemistry Scientist II/Senior Researcher

2 months ago

Boston, Massachusetts, United States NextRNA Therapeutics Full time

As a Biochemistry Scientist II / Senior Researcher at NextRNA Therapeutics, you will be part of a dynamic and innovative team dedicated to enhancing patient outcomes through advanced RNA-targeted therapies. Your role will be pivotal in merging biochemical methodologies with our drug development initiatives.

About You:

  • You possess a wealth of experience in utilizing cutting-edge biochemical techniques to address complex scientific challenges, evidenced by a robust publication history.
  • You are ready to leverage your diverse skill set to confront new scientific inquiries, including the creation of assays and methodologies to investigate novel targets and modalities.
  • You are driven, passionate, and committed to making a significant impact in the field.
  • You excel in collaborative environments, valuing teamwork as a core strength.
  • You are meticulous, organized, and detail-oriented in your approach to research.
  • You have a strong desire for knowledge, continuously seeking to learn and tackle difficult problems.
  • You thrive in a fast-paced setting, eager to push the boundaries of scientific possibilities.

Responsibilities:

  • Utilize your biochemistry expertise to develop functional and binding assays for RNA-binding proteins and/or RNAs in conjunction with small molecules.
  • Serve as the biochemistry lead on various projects, playing a crucial role in the drug discovery process.
  • Investigate and assess new biochemical techniques to bolster drug discovery efforts.
  • Design and implement experimental frameworks to elucidate protein and RNA interactions.
  • Establish, troubleshoot, and enhance biochemical screening assays.
  • Oversee and actively participate in collaborations with contract research organizations, working closely with a multidisciplinary team to screen and validate small molecule candidates.
  • Conduct independent experiments while collaborating within a highly interdisciplinary team.

Key Qualifications:

  • PhD with a minimum of 3 years of post-doctoral experience in Biochemistry or a related field.
  • At least 2 years of industry experience for Senior Scientist roles, ideally in an interdisciplinary setting with close collaboration with medicinal chemists.
  • A strong publication record from both PhD and post-doctoral work demonstrating expertise in Biochemistry.
  • Proficiency in developing functional assays using techniques such as TR-FRET, Alpha-LISA, and Fluorescent Polarization.
  • Preferred experience in RNA biochemistry, including synthesis, purification, characterization, and structural analysis using methods like crystallography, SHAPE-MaP, or NMR.
  • Experience in analyzing protein/protein, protein/RNA, RNA/small molecule, or protein/small molecule interactions using techniques such as DSF, ITC, and/or MST, particularly in the context of small molecule drug discovery.
  • Understanding of protein expression and purification processes.
  • Ability to excel in a fast-paced start-up environment.
  • Strong communication and interpersonal skills.

NextRNA Therapeutics embraces diversity and is committed to creating an inclusive environment for all employees. We welcome individuals from all backgrounds and experiences to contribute their unique perspectives to our mission.