Lead Scientist II, Engineering

1 week ago


Chicago, Illinois, United States AbbVie Full time
Job Overview

At AbbVie, we are dedicated to discovering and delivering groundbreaking medicines and solutions that tackle significant health challenges today while addressing future medical needs. Our goal is to make a profound impact on people's lives across various therapeutic areas, including immunology, oncology, neuroscience, and eye care, as well as through our Allergan Aesthetics portfolio. For more information about AbbVie, please visit our website.

Position Summary

Lead Scientist II, Engineering

The Process Research and Development division at AbbVie is at the forefront of creating synthetic methodologies to produce active pharmaceutical ingredients (APIs) that facilitate the advancement of AbbVie's product pipeline and ensure effective commercial manufacturing processes. We are looking for a highly driven individual with a solid history of achievements to join our API Pilot Plant Technical Operations (Tech Ops) team. This role will act as a crucial link between the scientific functions of Process Research and Development and the API Pilot Plant.

The successful candidate will play a key role in optimizing and scaling synthetic processes while aiding in the integration of these processes and innovative technologies into the API Pilot Plant. Additionally, the Scientist will provide technical guidance during production runs and support the transfer of technology to the commercial manufacturing site.

Key Responsibilities:
  • Oversee the management of processes entering the API Pilot Plant, including scheduling, equipment selection, materials tracking, authoring direction sets, conducting safety analyses, and executing pre-runs.
  • Engage in long-term capital planning for the Pilot Plant and explore expansions into new modalities, such as the manufacturing of long-acting injectables, lipid nanoparticles, and oligonucleotides.
  • Provide technical oversight for processes operating in the API Pilot Plant and troubleshoot issues in collaboration with project teams.
  • Offer strong technical mentorship to the TechOps group and project teams.
  • Review and document data for cGMP execution of chemical processes, including authoring campaign summary reports.
  • Identify, assess, and implement new technologies for the pilot plant while exploring opportunities to enhance operational efficiency with existing assets.
  • Support the implementation of Process Analytical Technology (PAT), including equipment specification, setup, data collection, and analysis.
  • Collaborate with project teams to ensure processes are safe and operational.
  • Partner with API development teams to optimize processes for scaling, identifying suitable equipment and configurations.
Qualifications:

Compensation and level will be aligned with experience.

  • BS, MS, or Ph.D. in Chemical Engineering or Chemistry with 9+ (BS), 7+ (MS), or 2+ (Ph.D.) years of relevant experience.
  • Familiarity with modeling software such as MatLab, Python, C++, Ansys, or COMSOL.
  • Proficient in analytical techniques including HPLC, GC, NMR, and microscopy.
  • Experience with Process Analytical Technology.
Preferred Qualifications:
  • Experience in laboratory experiments, process scale-up from lab to pilot plant, and/or transferring processes from pilot plant to commercial facilities.
  • Experience in an API Plant environment and familiarity with chemical process equipment and systems.
  • Knowledge of chemical processing unit operations, including reactions, membrane separation, chromatography, and tangential flow filtration.
  • Understanding of cGMP, process safety requirements, and OSHA chemical hygiene plans.
Key Leadership Competencies:
  • Demonstrated technical leadership and mentorship capabilities.
  • Ability to build strong relationships with peers and cross-functional partners to enhance performance.
  • Quick learner who can adapt and change direction as needed.
  • Commitment to continuous improvement and innovation.
  • Strong interpersonal and communication skills, with a proven ability to work effectively in a team environment.

AbbVie is an equal opportunity employer, committed to diversity and inclusion, and dedicated to hiring qualified individuals without discrimination based on race, color, religion, national origin, age, sex, disability, or any other legally protected status.



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