Principal Scientist/antibody Drug Conjugate
2 months ago
**Working with Us**
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology, neuroscience, and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
As part of the Discovery Biotherapeutics efforts at BMS, the Principal Scientist will play a key role in advancing antibody drug conjugates technologies at BMS.
A prove track record of hands-on experience with antibody-drug conjugation chemistry, analytical characterization and developability of ADCs is a must have for this position.
**Responsibilities**:
- The role will involve leading and carrying out laboratory experiments related to ADC conjugation, associated purification and analytical characterization of the conjugates
- Design, produce, and characterize antibody-drug conjugates (ADCs) with a high degree of independence
- Proactively advise and share knowledge and expert opinions with bench scientists, peers and senior management. Mentor staff in troubleshooting strategic and experimental issues
- Record of leading project teams through different stages of pre-clinical discovery
- Ensure highest standard of quality in antibody-conjugate productions in alignment with product development guidelines and QC criteria
- Collaborate with a diverse team of biologists and chemists to answer scientific questions and drive forward new conjugation platforms
- Leverage knowledge of bioconjugation and protein engineering to develop new therapeutic ADC technologies.
- Contribute to patents, publications, and technical reports.
**Basic Qualifications**:
Bachelor's Degree with 8+ years of academic or industry experience
Or
Master's Degree with 6+ years of academic or industry experience
Or
PhD with 4+ years of academic or industry experience
**Preferred Qualifications**:
A PhD with 4+ years of industry experience
Extensive hands-on experience with therapeutic antibody and ADC discovery
Deep knowledge of bioconjugation chemistries (lysine, inter-chain cysteine and/or site-specific cysteine and other) is needed.
Experience in development of purification strategies using various chromatographic techniques such as affinity, size exclusion, ion-exchange, hydrophobic interaction, and tangential flow filtration (TFF)
Experience in analytical characterization of ADCs including SEC, RP-HPLC, LC-MS, CE-SDS, ELISA, DSC, and HIC
Experience with biological assays such as measuring cytotoxic activity for ADC characterization.
Hands-on experience with siRNA/ASO conjugations and analytics is a plus.
Demonstrated record of scientific accomplishments and publications.
Excellent written and oral communication skills and ability to interpret results and contribute to multidisciplinary biologics discovery teams
**For California Sites**:
- The starting compensation for this job is a range from **$121,000 - $167,200**, plus incentive cash and stock opportunities (based on eligibility). The starting pay takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation is decided based on demonstrated experience. For more on benefits, please visit our BMS Careers site. Eligibility for specific benefits listed in our careers site may vary based on the job and location.**
**Uniquely Interesting Work, Life-changing Careers**
**On-site Protocol**
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to atten
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