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Adecco is assisting a pharmaceutical client who is seeking an outstanding Senior Scientist, Protein Sciences to lead our protein purification and characterization efforts. This position will be responsible for conducting antibody and protein purification at various scales, and for measuring key protein attributes by leveraging strong expertise in biophysical characterization and biochemical modification. This role provides a unique opportunity to contribute to the expansion of antibody discovery and engineering capabilities and new technologies for antibody drug discovery


Responsibilities:

  • Design and execute purification strategies for recombinant proteins from a variety of host cells (mammalian, bacterial cells).
  • Develop and optimize workflows for high-throughput purification and characterization of antibodies, bi-specifics, and other biologics modalities.
  • Design, develop and execute chromatography methods on AKTA, implement and conduct multi-step purification for challenging format such as bi-specific molecules.
  • Biophysical characterization of purified proteins using appropriate instrumentation, including but not limited to HPLC, Capillary electrophoresis, LC-MS, and DSF.
  • Prepare technical summaries, protocols, and maintenance of appropriate documentation.
  • Lead technology development for protein purification workflows.


Qualifications:

  • PhD in a relevant scientific area, such as antibody or protein engineering, protein biochemistry, or biotechnology, plus at least 4 years of professional experience in biologics research or MS degree in similar discipline with at least 6 years of relevant industry experience.
  • Extensive chromatography experience using AKTA instrumentation is required
  • Experience with biologics drug discovery and development is strongly desired.
  • Hands-on experience with HPLC instrumentation from Agilent or Vanquish.
  • Hands-on experience with SDS-PAGE, CE-SDS and other characterization techniques is required.
  • Familiar with construct design for challenging targets in various expression systems is desired, with a solid understanding of vector elements and utilization of solubility enhancing elements.
  • Experience with antibody and protein engineering is strongly preferred.