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Senior Researcher, Immunohistochemistry and Imaging

4 months ago

Cambridge, United States Eisai US Full time

At Eisai, satisfying unmet medical needs and increasing the benefits healthcare provides to patients, their families, and caregivers is Eisai's human health care (hhc) mission. We're a growing pharmaceutical company that is breaking through in neurology and oncology, with a strong emphasis on research and development. Our history includes the development of many innovative medicines, notably the discovery of the world's most widely-used treatment for Alzheimer's disease. As we continue to expand, we are seeking highly-motivated individuals who want to work in a fast-paced environment and make a difference. If this is your profile, we want to hear from you.

Job Summary

The Senior Researcher, IHC will contribute to our discovery biology efforts by conducting a wide variety of immunohistochemical studies on tissues from animal models. They will work with cross functional team members to assess effects of neuronal and glial cell modulation on neuronal biology and function. Responsibilities include preparing tissues for sectioning, generating tissue sections by microtomy and cryotomy, designing, validating, and performing immunohistochemistry, immunofluorescence and in situ hybridization experiments, imaging resulting slides by microscope or slide scanner, and analyzing the resulting images. The ideal candidate should have a background in neuroscience/ neuroimmunology, be well organized, proactive, and possess excellent technical and communication skills, as well as the ability to work collaboratively in a team environment. Flexibility and willingness to learn and master new techniques are critical. This position will develop along the scientific track.

Essential Functions

* Independently develop, optimize, and validate protocols for single and multiplexed immunohistochemistry (IHC), immunofluorescence (IF) and in-situ hybridization (ISH)


* Prepare and section frozen floating and OCT embedded tissue samples and perform routine histology staining procedures


* Perform a wide variety of IF, IHC, and ISH staining protocols


* Acquire images of stained sections using microscopes (confocal, epifluorescence) and slide scanners


* Independently perform advanced image analysis and quantification, developing novel protocols as needed


* Analyze and deliver results in timely fashion and communicate research findings to project teams


* Maintain laboratory equipment and reagent inventory


* Generate accurate and detailed study records and maintain an electronic lab notebook


* Work effectively within a broad cross-functional team



Requirements

* M.S. or B.S. plus 2+ years relevant experience in neuroscience, neuroimmunology or a related field


* A background in neuroimmunology and/ or neurodegeneration is preferred


* Extensive experience with tissue embedding, tissue sectioning (microtomy and cryotomy), and manual immunohistochemistry and immunofluorescence staining is required


* Extensive experience with confocal, epifluorescence, and bright field microscopy required


* Experience with image analysis software (Imaris, Halo, Matlab, etc) required


* Experience with digital slide scanners preferred


* Experience with pre-clinical species (e.g. mouse) required and experience with mouse brain sectioning/ staining strongly preferred



Eisai is an equal opportunity employer and as such, is committed in policy and in practice to recruit, hire, train, and promote in all job qualifications without regard to race, color, religion, gender, age, national origin, citizenship status, marital status, sexual orientation, gender identity, disability or veteran status. Similarly, considering the need for reasonable accommodations, Eisai prohibits discrimination against persons because of disability, including disabled veterans.

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