Research and Development Associate

5 days ago


Cambridge, Massachusetts, United States Mindlance Full time
Job Title: Research and Development Associate

We are seeking a highly skilled Research and Development Associate to join our team at Mindlance. As a key member of our Biologics Drug Discovery (BDD) team, you will contribute to the design, optimization, and development of therapeutics to improve the lives of patients with neurodegenerative diseases.

Key Responsibilities:
  • Establish and perform in vivo PK/PD studies for therapeutic proteins, antisense oligonucleotides, viral vectors, and other modalities with CNS delivery/targeting properties.
  • Perform in vivo immunizations to generate antigen-specific antibodies from B cells by next-generation sequencing or hybridoma production.
  • Contribute to research efforts on specific projects involving Client BBB targets and other modalities.
  • Perform biochemical and molecular biology assays to enable PK/PD analysis of therapeutic candidate drugs, including ELISA/MSD and qPCR.
  • Work as a part of a collaborative and cross-functional team.
  • Perform data analysis, maintain electronic laboratory notebooks, and present data.
Qualifications:
  • Education: BS, MS in Biochemistry, Analytical Chemistry, or related major.
  • Industry experience: 3-5 years.
  • Expertise with in vivo procedures, including injections (IV, SC, IP), blood collection, and necropsy/tissue collection (brain, spinal cord, muscle, and other tissues).
  • Experience with in vivo immunization techniques for antibody generation.
  • Ability to establish and perform biochemical and molecular assays, including ELISA/MSD, qPCR, BCA, and other relevant techniques.
  • Strong communication, organization, and documentation skills.
  • Quantitative data analysis using GraphPad Prism, MS Office, or other relevant software.
Preferred Skills:
  • Knowledge in BBB field and CNS delivery technologies, including viral-delivery technologies and receptor-mediated transcytosis.
  • Knowledge of basic neurobiology, neurodegenerative diseases, and drug discovery.
  • Ability to establish and perform biochemical and molecular assays, including FACS and internalization assays using cellular imaging.
  • Experience with immunohistochemistry, histology, and microscopy.
  • Experience in handling and working with large molecules.

Mindlance is an Equal Opportunity Employer and does not discriminate in employment on the basis of – Minority/Gender/Disability/Religion/LGBTQI/Age/Veterans.


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